Interleukin-33 receptor | Immunoglobulin-like family of IL-1 receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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Interleukin-33 receptor

target has curated data in GtoImmuPdb

Target id: 1906

Nomenclature: Interleukin-33 receptor

Family: Immunoglobulin-like family of IL-1 receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Quaternary Structure: Subunits
Interleukin-1 receptor-like 1 (Ligand-binding subunit)
IL-1 receptor accessory protein (Other subunit)
Natural/Endogenous Ligands
IL-33 {Sp: Human}
Antibody Comments
The anti-IL33R immunomodulatory monoclonal CNTO 7160 (Janssen Research & Development) has entered Phase I clinical trial in patients with asthma and atopic dermatitis (see NCT02345928).
Immunopharmacology Comments
The functional IL-33 receptor is a heterodimer containing interleukin-1 receptor-like 1 (IL1RL1) as the ligand binding moeity and the IL-1 receptor accessory protein (IL1RAP).

How to cite this page

Immunoglobulin-like family of IL-1 receptors: Interleukin-33 receptor. Last modified on 22/03/2017. Accessed on 17/06/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1906.