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NIMA related kinase 9

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Target not currently curated in GtoImmuPdb

Target id: 2124

Nomenclature: NIMA related kinase 9

Abbreviated Name: NEK9

Family: NIMA (never in mitosis gene a)- related kinase (NEK) family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 979 14q24.3 NEK9 NIMA related kinase 9
Mouse - 984 12 D1 Nek9 NIMA (never in mitosis gene a)-related expressed kinase 9
Rat - 958 6 q31 Nek9 NIMA-related kinase 9
Previous and Unofficial Names Click here for help
NERCC | NIMA-related kinase 9
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/NEK9
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
K-252a Small molecule or natural product Hs Inhibitor Inhibition 14.7
SB 218078 Small molecule or natural product Hs Inhibitor Inhibition 23.4
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 27.2
PKR inhibitor Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 32.0
Cdk1/2 inhibitor III Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 39.1
dovitinib Small molecule or natural product Hs Inhibitor Inhibition 58.9
midostaurin Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 64.4
JAK3 inhibitor VI Small molecule or natural product Hs Inhibitor Inhibition 66.3
Syk inhibitor Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 67.3
aminopurvalanol A Small molecule or natural product Hs Inhibitor Inhibition 69.4
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

How to cite this page

NIMA (never in mitosis gene a)- related kinase (NEK) family: NIMA related kinase 9. Last modified on 29/01/2016. Accessed on 01/03/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2124.