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PTEN induced kinase 1

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Target not currently curated in GtoImmuPdb

Target id: 2161

Nomenclature: PTEN induced kinase 1

Abbreviated Name: PINK1

Family: NKF2 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 581 1p36.12 PINK1 PTEN induced kinase 1
Mouse 1 580 4 D3 Pink1 PTEN induced putative kinase 1
Rat - 257 5 q36 Pink1 PTEN induced kinase 1
Previous and Unofficial Names Click here for help
brpk | Parkinson disease (autosomal recessive) 6
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
MTK458 Small molecule or natural product Hs Activation - - 1
Activator Comments
Direct binding of MTK458 to PINK1 was demonstrated using a nano-BRET proximity assay [1].
Immuno Process Associations
Immuno Process:  Cellular signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Parkinson disease 6, autosomal recessive early-onset; PARK6
Synonyms: Parkinson's disease [Disease Ontology: DOID:14330]
Young adult-onset Parkinsonism [Orphanet: ORPHA2828]
Disease Ontology: DOID:14330
OMIM: 605909
Orphanet: ORPHA2828


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1. Chin RM, Rakhit R, Ditsworth D, Wang C, Bartholomeus J, Liu S, Mody A, Laishu A, Eastes A, Tai C et al.. (2023) Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv, Preprint. [PMID:36824886]

How to cite this page

NKF2 family: PTEN induced kinase 1. Last modified on 14/11/2023. Accessed on 26/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY,