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PTEN induced kinase 1

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Target not currently curated in GtoImmuPdb

Target id: 2161

Nomenclature: PTEN induced kinase 1

Abbreviated Name: PINK1

Family: NKF2 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 581 1p36.12 PINK1 PTEN induced kinase 1
Mouse 1 580 4 D3 Pink1 PTEN induced putative kinase 1
Rat - 257 5 q36 Pink1 PTEN induced kinase 1
Previous and Unofficial Names Click here for help
brpk | Parkinson disease (autosomal recessive) 6
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

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Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
MTK458 Small molecule or natural product Hs Activation - - 1
[1]
Activator Comments
Direct binding of MTK458 to PINK1 was demonstrated using a nano-BRET proximity assay [1].
Immuno Process Associations
Immuno Process:  Cellular signalling
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Parkinson disease 6, autosomal recessive early-onset; PARK6
Synonyms: Parkinson's disease [Disease Ontology: DOID:14330]
Young adult-onset Parkinsonism [Orphanet: ORPHA2828]
Disease Ontology: DOID:14330
OMIM: 605909
Orphanet: ORPHA2828

References

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1. Chin RM, Rakhit R, Ditsworth D, Wang C, Bartholomeus J, Liu S, Mody A, Laishu A, Eastes A, Tai C et al.. (2023) Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv, Preprint. [PMID:36824886]

How to cite this page

NKF2 family: PTEN induced kinase 1. Last modified on 14/11/2023. Accessed on 23/02/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2161.