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PTEN induced kinase 1

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Target not currently curated in GtoImmuPdb

Target id: 2161

Nomenclature: PTEN induced kinase 1

Abbreviated Name: PINK1

Family: NKF2 family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 581 1p36.12 PINK1 PTEN induced kinase 1
Mouse 1 580 4 D3 Pink1 PTEN induced putative kinase 1
Rat - 257 5 q36 Pink1 PTEN induced kinase 1
Previous and Unofficial Names Click here for help
brpk | Parkinson disease (autosomal recessive) 6
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 4 GO processes
GO:0016567 protein ubiquitination IMP
GO:0031396 regulation of protein ubiquitination IDA
GO:0031398 positive regulation of protein ubiquitination ISS
GO:0051443 positive regulation of ubiquitin-protein transferase activity TAS
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Parkinson disease 6, autosomal recessive early-onset; PARK6
Synonyms: Parkinson's disease [Disease Ontology: DOID:14330]
Young adult-onset Parkinsonism [Orphanet: ORPHA2828]
Disease Ontology: DOID:14330
OMIM: 605909
Orphanet: ORPHA2828

How to cite this page

NKF2 family: PTEN induced kinase 1. Last modified on 18/09/2018. Accessed on 25/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2161.