Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	519	18q11.2	RIOK3	RIO kinase 3
Mouse	-	519	18 A2	Riok3	RIO kinase 3
Rat	-	519	18 p13	Riok3	RIO kinase 3

Previous and Unofficial Names

SUDD

Database Links
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5659 (Hs)
Ensembl Gene	ENSG00000101782 (Hs), ENSMUSG00000024404 (Mm), ENSRNOG00000023376 (Rn)
Entrez Gene	8780 (Hs), 66878 (Mm), 361293 (Rn)
Human Protein Atlas	ENSG00000101782 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:8780 (Hs), mmu:66878 (Mm), rno:361293 (Rn)
OMIM	603579 (Hs)
Pharos	O14730 (Hs)
RefSeq Nucleotide	NM_003831 (Hs), NM_024182 (Mm), NM_001108423 (Rn)
RefSeq Protein	NP_003822 (Hs), NP_077144 (Mm), NP_001101893 (Rn)
UniProtKB	O14730 (Hs), Q9DBU3 (Mm)
Wikipedia	RIOK3 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: RIOK3
Ligand Sp. Type Action Value Parameter lestaurtinib Hs Inhibitor Inhibition 8.1 pKd KW-2449 Hs Inhibitor Inhibition 7.2 pKd staurosporine Hs Inhibitor Inhibition 7.1 pKd fedratinib Hs Inhibitor Inhibition 7.0 pKd tamatinib Hs Inhibitor Inhibition 6.7 pKd PHA-665752 Hs Inhibitor Inhibition 6.4 pKd midostaurin Hs Inhibitor Inhibition 6.4 pKd tozasertib Hs Inhibitor Inhibition 6.2 pKd ruboxistaurin Hs Inhibitor Inhibition 6.2 pKd A-674563 Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0039534 negative regulation of MDA-5 signaling pathway IMP GO:0045089 positive regulation of innate immune response IMP click arrow to show/hide IEA associations GO:0045087 innate immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:0039534 negative regulation of MDA-5 signaling pathway IMP GO:0045089 positive regulation of innate immune response IMP

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:0032728 positive regulation of interferon-beta production IMP GO:0039534 negative regulation of MDA-5 signaling pathway IMP

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0039534 negative regulation of MDA-5 signaling pathway IMP