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striated muscle enriched protein kinase

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Target not currently curated in GtoImmuPdb

Target id: 2203

Nomenclature: striated muscle enriched protein kinase

Abbreviated Name: SPEG

Family: Trio family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 3267 2q35 SPEG striated muscle enriched protein kinase
Mouse - 3262 1 38.88 cM Speg SPEG complex locus
Rat - 3259 9q33 Speg striated muscle enriched protein kinase
Previous and Unofficial Names Click here for help
aortic preferentially expressed gene 1 | APEG1 | BPEG | SPEG complex locus
Database Links Click here for help
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  X-ray structure of engineered human aortic preferentially expressed protein-1 (APEG-1, SPEG).
PDB Id:  1U2H
Resolution:  0.96Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Myopathy, centronuclear, 5; CNM5
Synonyms: Autosomal recessive centronuclear myopathy [Orphanet: ORPHA169186]
Centronuclear myopathy [Disease Ontology: DOID:14717]
Disease Ontology: DOID:14717
OMIM: 615959
Orphanet: ORPHA169186

References

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1. Manjasetty BA, Niesen FH, Scheich C, Roske Y, Goetz F, Behlke J, Sievert V, Heinemann U, Büssow K. (2005) X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1). BMC Struct Biol, 5: 21. [PMID:16354304]

How to cite this page

Trio family: striated muscle enriched protein kinase. Last modified on 27/03/2019. Accessed on 18/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2203.