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trio Rho guanine nucleotide exchange factor

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Target not currently curated in GtoImmuPdb

Target id: 2255

Nomenclature: trio Rho guanine nucleotide exchange factor

Abbreviated Name: TRIO

Family: Trio family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 3097 5p15.2 TRIO trio Rho guanine nucleotide exchange factor
Mouse - 3102 15 B1 Trio triple functional domain (PTPRF interacting)
Rat - 3104 2q22 Trio trio Rho guanine nucleotide exchange factor
Previous and Unofficial Names Click here for help
Solo | triple functional domain (PTPRF interacting)
Database Links Click here for help
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the first DH/PH domain of Trio to 1.7 A.
PDB Id:  1NTY
Resolution:  1.7Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

References

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1. Skowronek KR, Guo F, Zheng Y, Nassar N. (2004) The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. J Biol Chem, 279 (36): 37895-907. [PMID:15199069]

How to cite this page

Trio family: trio Rho guanine nucleotide exchange factor. Last modified on 18/08/2014. Accessed on 23/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2255.