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Target not currently curated in GtoImmuPdb
Target id: 2280
Nomenclature: WNK lysine deficient protein kinase 1
Abbreviated Name: WNK1
Family: Wnk family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 2382 | 12p13.33 | WNK1 | WNK lysine deficient protein kinase 1 | |
Mouse | - | 2377 | 6 F1 | Wnk1 | WNK lysine deficient protein kinase 1 | |
Rat | - | 2126 | 4q42 | Wnk1 | WNK lysine deficient protein kinase 1 |
Previous and Unofficial Names ![]() |
hereditary sensory neuropathy, type II | Hsn2 | prkwnk1 |
Database Links ![]() |
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Alphafold | Q9H4A3 (Hs), P83741 (Mm), Q9JIH7 (Rn) |
BRENDA | 2.7.11.1 |
ChEMBL Target | CHEMBL1075173 (Hs), CHEMBL2176799 (Mm) |
Ensembl Gene | ENSG00000060237 (Hs), ENSMUSG00000045962 (Mm), ENSRNOG00000009956 (Rn) |
Entrez Gene | 65125 (Hs), 232341 (Mm), 116477 (Rn) |
Human Protein Atlas | ENSG00000060237 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:65125 (Hs), mmu:232341 (Mm), rno:116477 (Rn) |
OMIM | 605232 (Hs) |
Orphanet | ORPHA120531 (Hs) |
Pharos | Q9H4A3 (Hs) |
RefSeq Nucleotide | NM_001184985 (Hs), NM_198703 (Mm), NM_001002823 (Rn) |
RefSeq Protein | NP_061852 (Hs), NP_941992 (Mm), NP_001002823 (Rn) |
UniProtKB | Q9H4A3 (Hs), P83741 (Mm), Q9JIH7 (Rn) |
Wikipedia | WNK1 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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Clinically-Relevant Mutations and Pathophysiology ![]() |
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1. Min X, Lee BH, Cobb MH, Goldsmith EJ. (2004) Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure, 12 (7): 1303-11. [PMID:15242606]
2. Yagi YI, Abe K, Ikebukuro K, Sode K. (2009) Kinetic mechanism and inhibitor characterization of WNK1 kinase. Biochemistry, 48 (43): 10255-66. [PMID:19739668]
Wnk family: WNK lysine deficient protein kinase 1. Last modified on 23/09/2015. Accessed on 16/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2280.