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WNK lysine deficient protein kinase 1

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Target not currently curated in GtoImmuPdb

Target id: 2280

Nomenclature: WNK lysine deficient protein kinase 1

Abbreviated Name: WNK1

Family: Wnk family

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2382 12p13.33 WNK1 WNK lysine deficient protein kinase 1
Mouse - 2377 6 F1 Wnk1 WNK lysine deficient protein kinase 1
Rat - 2126 4q42 Wnk1 WNK lysine deficient protein kinase 1
Previous and Unofficial Names Click here for help
hereditary sensory neuropathy, type II | Hsn2 | prkwnk1
Database Links Click here for help
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the kinase domain of WNK1.
PDB Id:  3FPQ
Resolution:  1.8Å
Species:  Rat
References:  1
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PP1 Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 4.9 pKi 2
pKi 4.9 (Ki 1.27x10-5 M) [2]
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0050852 T cell receptor signaling pathway ISS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 5 GO processes
GO:0010820 positive regulation of T cell chemotaxis IMP
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway ISS
GO:0097022 lymphocyte migration into lymph node ISS
GO:1903038 negative regulation of leukocyte cell-cell adhesion IMP
GO:1990869 cellular response to chemokine IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 2 GO processes
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway ISS
GO:1990869 cellular response to chemokine IMP
Immuno Process:  Immune regulation
GO Annotations:  Associated to 2 GO processes
GO:0010820 positive regulation of T cell chemotaxis IMP
GO:0050852 T cell receptor signaling pathway ISS
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0010820 positive regulation of T cell chemotaxis IMP
GO:0097022 lymphocyte migration into lymph node ISS
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Neuropathy, hereditary sensory and autonomic, type IIA; HSAN2A
Synonyms: Hereditary sensory and autonomic neuropathy [Disease Ontology: DOID:11533]
Hereditary sensory and autonomic neuropathy type 2 [Orphanet: ORPHA970]
Disease Ontology: DOID:11533
OMIM: 201300
Orphanet: ORPHA970
Disease:  Pseudohypoaldosteronism, type IIC; PHA2C
Synonyms: Pseudohypoaldosteronism [Disease Ontology: DOID:4479]
Pseudohypoaldosteronism type 2C [Orphanet: ORPHA88940]
Disease Ontology: DOID:4479
OMIM: 614492
Orphanet: ORPHA88940

References

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1. Min X, Lee BH, Cobb MH, Goldsmith EJ. (2004) Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure, 12 (7): 1303-11. [PMID:15242606]

2. Yagi YI, Abe K, Ikebukuro K, Sode K. (2009) Kinetic mechanism and inhibitor characterization of WNK1 kinase. Biochemistry, 48 (43): 10255-66. [PMID:19739668]

How to cite this page

Wnk family: WNK lysine deficient protein kinase 1. Last modified on 23/09/2015. Accessed on 23/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2280.