WNK lysine deficient protein kinase 1 | Wnk family | IUPHAR/BPS Guide to PHARMACOLOGY

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WNK lysine deficient protein kinase 1

Target not currently curated in GtoImmuPdb

Target id: 2280

Nomenclature: WNK lysine deficient protein kinase 1

Abbreviated Name: WNK1

Family: Wnk family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2382 12p13.3 WNK1 WNK lysine deficient protein kinase 1
Mouse - 2377 6 F1 Wnk1 WNK lysine deficient protein kinase 1
Rat - 2634 4q42 Wnk1 WNK lysine deficient protein kinase 1
Previous and Unofficial Names
hereditary sensory neuropathy, type II | Hsn2 | prkwnk1
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the kinase domain of WNK1.
PDB Id:  3FPQ
Resolution:  1.8Å
Species:  Rat
References:  1
Enzyme Reaction
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
PP1 Hs Inhibition 4.9 pKi 2
pKi 4.9 (Ki 1.27x10-5 M) [2]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Neuropathy, hereditary sensory and autonomic, type IIA; HSAN2A
Synonyms: Hereditary sensory and autonomic neuropathy [Disease Ontology: DOID:11533]
Hereditary sensory and autonomic neuropathy type 2 [Orphanet: ORPHA970]
Disease Ontology: DOID:11533
OMIM: 201300
Orphanet: ORPHA970
Disease:  Pseudohypoaldosteronism, type IIC; PHA2C
Synonyms: Pseudohypoaldosteronism [Disease Ontology: DOID:4479]
Pseudohypoaldosteronism type 2C [Orphanet: ORPHA88940]
Disease Ontology: DOID:4479
OMIM: 614492
Orphanet: ORPHA88940

References

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1. Min X, Lee BH, Cobb MH, Goldsmith EJ. (2004) Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure, 12 (7): 1303-11. [PMID:15242606]

2. Yagi YI, Abe K, Ikebukuro K, Sode K. (2009) Kinetic mechanism and inhibitor characterization of WNK1 kinase. Biochemistry, 48 (43): 10255-66. [PMID:19739668]

How to cite this page

Wnk family: WNK lysine deficient protein kinase 1. Last modified on 23/09/2015. Accessed on 20/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2280.