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BRCA1 associated protein 1

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Target not currently curated in GtoImmuPdb

Target id: 2332

Nomenclature: BRCA1 associated protein 1

Family: C12: Ubiquitin C-terminal hydrolase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 729 3p21.1 BAP1 BRCA1 associated protein 1
Mouse - 728 14 B Bap1 Brca1 associated protein 1
Rat - 727 16p16 Bap1 Brca1 associated protein 1
Previous and Unofficial Names Click here for help
ubiquitin C-terminal hydrolase X4 | UCHL2 | uch-x4 | hucep-6 | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Database Links Click here for help
Specialist databases
MEROPS C12.004 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.19.12
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0050727 regulation of inflammatory response IMP
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GO:1900015 regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes, IEA only
GO:0050727 regulation of inflammatory response IMP
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GO:0061519 macrophage homeostasis IEA
GO:1900015 regulation of cytokine production involved in inflammatory response IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:1900015 regulation of cytokine production involved in inflammatory response IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Malignant mesothelioma
Disease Ontology: DOID:1790
OMIM: 156240
Disease:  Tumor predisposition syndrome
Synonyms: BAP1-related tumor predisposition syndrome [Orphanet: ORPHA289539]
OMIM: 614327
Orphanet: ORPHA289539

How to cite this page

C12: Ubiquitin C-terminal hydrolase: BRCA1 associated protein 1. Last modified on 29/01/2016. Accessed on 28/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2332.