cathepsin Z | C1: Papain | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

cathepsin Z

Target not currently curated in GtoImmuPdb

Target id: 2354

Nomenclature: cathepsin Z

Family: C1: Papain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 303 20q13.32 CTSZ cathepsin Z
Mouse - 306 2 H4 Ctsz cathepsin Z
Rat - 306 3 Ctsz cathepsin Z
Previous and Unofficial Names
CTSX | carboxypeptidase LB | cathepsin B2 | cathepsin IV | cathepsin Y | lysosomal carboxypeptidase B | cathepsin X | CATX | cysteine-type carboxypeptidase
Database Links
Specialist databases
MEROPS C01.013 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
odanacatib Hs Inhibition 8.0 pIC50 1
pIC50 8.0 (IC50 1x10-8 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS


Show »

1. Gauthier JY, Chauret N, Cromlish W, Desmarais S, Duong le T, Falgueyret JP, Kimmel DB, Lamontagne S, Léger S, LeRiche T et al.. (2008) The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg. Med. Chem. Lett., 18 (3): 923-8. [PMID:18226527]

How to cite this page

C1: Papain: cathepsin Z. Last modified on 28/07/2015. Accessed on 04/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,