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target has curated data in GtoImmuPdb
Target id: 2456
Nomenclature: integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)
Family: Integrins
Quaternary Structure: Complexes |
integrin αLβ2 |
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 769 | 21q22.3 | ITGB2 | integrin subunit beta 2 | |
Mouse | 1 | 771 | 10 39.72 cM | Itgb2 | integrin beta 2 | |
Rat | - | 768 | 20p12 | Itgb2 | integrin subunit beta 2 |
Previous and Unofficial Names |
CD antigen CD18 | Integrin beta-2 | integrin, beta 2 | integrin, beta 2 (antigen CD18 (p95) | LFA-1 | lymphocyte function-associated antigen 1 |
Database Links | |
Alphafold | P05107 (Hs), P11835 (Mm) |
CATH/Gene3D | 1.20.5.630 |
ChEMBL Target | CHEMBL3631 (Hs) |
Ensembl Gene | ENSG00000160255 (Hs), ENSMUSG00000000290 (Mm), ENSRNOG00000001224 (Rn) |
Entrez Gene | 3689 (Hs), 16414 (Mm), 309684 (Rn) |
Human Protein Atlas | ENSG00000160255 (Hs) |
KEGG Gene | hsa:3689 (Hs), mmu:16414 (Mm), rno:309684 (Rn) |
OMIM | 600065 (Hs) |
Pharos | P05107 (Hs) |
RefSeq Nucleotide | NM_001127491 (Hs), NM_000211 (Hs), NM_008404 (Mm), NM_001037780 (Rn) |
RefSeq Protein | NP_000202 (Hs), NP_001120963 (Hs), NP_032430 (Mm), NP_001032869 (Rn) |
UniProtKB | P05107 (Hs), P11835 (Mm) |
Wikipedia | ITGB2 (Hs) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
ITGB2 is the beta component of the β2 integrins. It forms αβ heterodimers with the CD11 alpha subunits ITGAL (αL aka CD11a forming integrin LFA-1), ITGAM (αM aka CD11b, forming integrin Mac-1) and ITGAX (αX aka CD11c, forming integrin p150/95). Beta2-integrins are essential for leukocyte extravasation to sites of infection (i.e. leukocyte trafficking), and other immunological processes including neutrophil phagocytosis and ROS production, and T cell activation. Their absence causes a leukocyte adhesion deficiency, which manifests clinically as recurrent severe infections, defective wound healing and neutrophilia [3]. |
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||
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1. Dinauer MC. (2019) Inflammatory consequences of inherited disorders affecting neutrophil function. Blood, 133 (20): 2130-2139. [PMID:30898864]
2. Fagerholm SC, Guenther C, Llort Asens M, Savinko T, Uotila LM. (2019) Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease. Front Immunol, 10: 254. [PMID:30837997]
3. Kishimoto TK, Hollander N, Roberts TM, Anderson DC, Springer TA. (1987) Heterogeneous mutations in the beta subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency. Cell, 50 (2): 193-202. [PMID:3594570]
4. Liles WC, Dale DC, Price TH, Gaviria JM, Turner T, Saoud J, Frumkin LR. (2000) Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody. Cytokines Cell Mol Ther, 6 (3): 121-6. [PMID:11140880]
5. Sun B, Chen Q, Dong X, Liu D, Hou J, Wang W, Ying W, Hui X, Zhou Q, Yao H et al.. (2019) Report of a Chinese Cohort with Leukocyte Adhesion Deficiency-I and Four Novel Mutations. J Clin Immunol, 39 (3): 309-315. [PMID:30919141]
6. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Exp Neurol, 153 (2): 223-33. [PMID:9784282]