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Gene and Protein Information  |
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| class B G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 440 | 2q14.2 | SCTR | secretin receptor | 1,11,13 |
| Mouse | 7 | 447 | 1 E2.3 | Sctr | secretin receptor | |
| Rat | 7 | 449 | 13q11 | Sctr | secretin receptor | 9 |
| Previous and Unofficial Names |
| SCT-R |
| Database Links |
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| Specialist databases | |
| GPCRdb | sctr_human (Hs), sctr_mouse (Mm), sctr_rat (Rn) |
| Other databases | |
| Alphafold | P47872 (Hs), Q5FWI2 (Mm), P23811 (Rn) |
| CATH/Gene3D | 4.10.1240.10 |
| ChEMBL Target | CHEMBL1925 (Hs) |
| DrugBank Target | P47872 (Hs) |
| Ensembl Gene | ENSG00000080293 (Hs), ENSMUSG00000026387 (Mm), ENSRNOG00000049766 (Rn) |
| Entrez Gene | 6344 (Hs), 319229 (Mm), 81779 (Rn) |
| Human Protein Atlas | ENSG00000080293 (Hs) |
| KEGG Gene | hsa:6344 (Hs), mmu:319229 (Mm), rno:81779 (Rn) |
| OMIM | 182098 (Hs) |
| Pharos | P47872 (Hs) |
| RefSeq Nucleotide | NM_002980 (Hs), NM_001012322 (Mm), NM_031115 (Rn) |
| RefSeq Protein | NP_002971 (Hs), NP_001012322 (Mm), NP_112377 (Rn) |
| UniProtKB | P47872 (Hs), Q5FWI2 (Mm), P23811 (Rn) |
| Wikipedia | SCTR (Hs) |
| Natural/Endogenous Ligands |
| secretin {Sp: Human} , secretin {Sp: Mouse} , secretin {Sp: Rat} |
| VIP {Sp: Human, Mouse, Rat} |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific agonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gs family | Adenylyl cyclase stimulation |
| References: | |
| Tissue Distribution
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| Expression Datasets |
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| There appear to be important species differences in the cellular and organ distribution of secretin and secretin family receptors. The best example of this is the confusing series of observations in pancreas of guinea-pig, rat, and human [10,15]. There are also differences in the pharmacologic profile of secretin receptors from different species, despite minimal changes in primary structure. Rat and human secretin receptors have very different binding affinities for VIP that have been attributed to a single receptor residue [8]. |
1. Chow BK. (1995) Molecular cloning and functional characterization of a human secretin receptor. Biochem Biophys Res Commun, 212 (1): 204-11. [PMID:7612008]
2. Chow BK, Cheung KH, Tsang EM, Leung MC, Lee SM, Wong PY. (2004) Secretin controls anion secretion in the rat epididymis in an autocrine/paracrine fashion. Biol Reprod, 70 (6): 1594-9. [PMID:14749298]
3. Davis RJ, Page KJ, Dos Santos Cruz GJ, Harmer DW, Munday PW, Williams SJ, Picot J, Evans TJ, Sheldrick RL, Coleman RA et al.. (2004) Expression and functions of the duodenal peptide secretin and its receptor in human lung. Am J Respir Cell Mol Biol, 31 (3): 302-8. [PMID:15191914]
4. Dong M, Wang Y, Hadac EM, Pinon DI, Holicky E, Miller LJ. (1999) Identification of an interaction between residue 6 of the natural peptide ligand and a distinct residue within the amino-terminal tail of the secretin receptor. J Biol Chem, 274 (27): 19161-7. [PMID:10383421]
5. Ganguli SC, Park CG, Holtmann MH, Hadac EM, Kenakin TP, Miller LJ. (1998) Protean effects of a natural peptide agonist of the G protein-coupled secretin receptor demonstrated by receptor mutagenesis. J Pharmacol Exp Ther, 286 (2): 593-8. [PMID:9694908]
6. Gourlet P, Vandermeers A, Vertongen P, Rathe J, De Neef P, Cnudde J, Waelbroeck M, Robberecht P. (1997) Development of high affinity selective VIP1 receptor agonists. Peptides, 18 (10): 1539-45. [PMID:9437714]
7. Haffar BM, Hocart SJ, Coy DH, Mantey S, Chiang HC, Jensen RT. (1991) Reduced peptide bond pseudopeptide analogues of secretin. A new class of secretin receptor antagonists. J Biol Chem, 266 (1): 316-22. [PMID:1702423]
8. Holtmann MH, Hadac EM, Ulrich CD, Miller LJ. (1996) Molecular basis and species specificity of high affinity binding of vasoactive intestinal polypeptide by the rat secretin receptor. J Pharmacol Exp Ther, 279 (2): 555-60. [PMID:8930157]
9. Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S. (1991) Molecular cloning and expression of a cDNA encoding the secretin receptor. EMBO J, 10 (7): 1635-41. [PMID:1646711]
10. Jensen RT, Gardner JD. (1980) Interaction of cholecystokinin with specific membrane receptors on pancreatic acinar cells. Proc Natl Acad Sci USA, 77: 2079-2083. [PMID:6246521]
11. Jiang S, Ulrich C. (1995) Molecular cloning and functional expression of a human pancreatic secretin receptor. Biochem Biophys Res Commun, 207 (3): 883-90. [PMID:7864894]
12. Lee SM, Chen L, Chow BK, Yung WH. (2005) Endogenous release and multiple actions of secretin in the rat cerebellum. Neuroscience, 134 (2): 377-86. [PMID:15963647]
13. Mark HF, Chow BK. (1995) Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry. Genomics, 29 (3): 817-8. [PMID:8575789]
14. Ng SS, Pang RT, Chow BK, Cheng CH. (1999) Real-time evaluation of human secretin receptor activity using cytosensor microphysiometry. J Cell Biochem, 72 (4): 517-27. [PMID:10022611]
15. Robberecht P, De Neef P, Waelbroeck M, Camus JC, Scemama JL, Fourmy D, Pradayrol L, Vaysse N, Christophe J. (1988) Secretin receptors in human pancreatic membranes. Pancreas, 3 (5): 529-35. [PMID:3186683]
16. Tay J, Goulet M, Rusche J, Boismenu R. (2004) Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain. Neurosci Lett, 366 (2): 176-81. [PMID:15276242]
17. Ulrich 2nd CD, Wood P, Hadac EM, Kopras E, Whitcomb DC, Miller LJ. (1998) Cellular distribution of secretin receptor expression in rat pancreas. Am J Physiol, 275 (6 Pt 1): G1437-44. [PMID:9843782]
