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phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

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Target not currently curated in GtoImmuPdb

Target id: 2612

Nomenclature: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Abbreviated Name: GART

Family: 2.1.2.- Hydroxymethyl-, formyl- and related transferases, 6.3.3.- Cyclo-ligases, Nucleoside synthesis and metabolism

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1010 21q22.11 GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Mouse - 1010 16 53.18 cM Gart phosphoribosylglycinamide formyltransferase
Rat - - 11q11 Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Previous and Unofficial Names Click here for help
PGFT | PRGS | trifunctional purine biosynthetic protein adenosine-3 | phosphoribosylglycinamide formyltransferase
Database Links Click here for help
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.1.2.2
EC Number: 6.3.3.1
EC Number: 6.3.4.13

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
pemetrexed Small molecule or natural product Approved drug Mm Inhibition 5.0 pKi 1
pKi 5.0 (Ki 9.3x10-6 M) [1]

References

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1. Shih C, Habeck LL, Mendelsohn LG, Chen VJ, Schultz RM. (1998) Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv. Enzyme Regul., 38: 135-52. [PMID:9762351]

How to cite this page

2.1.2.- Hydroxymethyl-, formyl- and related transferases: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase. Last modified on 28/11/2018. Accessed on 25/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2612.