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Nucleoside synthesis and metabolism C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The de novo synthesis and salvage of nucleosides have been targetted for therapeutic advantage in the treatment of particular cancers and gout. Dihydrofolate reductase produces tetrahydrofolate, a cofactor required for synthesis of purines, pyrimidines and amino acids. GART allows formylation of phosphoribosylglycinamide, an early step in purine biosynthesis. Dihydroorotate dehydrogenase produces orotate, a key intermediate in pyrimidine synthesis. IMP dehydrogenase generates xanthosine monophosphate, an intermediate in GTP synthesis.

Enzymes

DHFR (dihydrofolate reductase) C Show summary » More detailed page

GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase) C Show summary » More detailed page

DHODH (dihydroorotate dehydrogenase (quinone)) C Show summary » More detailed page

IMPDH1 (inosine monophosphate dehydrogenase 1) C Show summary » More detailed page

IMPDH2 (inosine monophosphate dehydrogenase 2) C Show summary » More detailed page

TYMS (thymidylate synthetase) C Show summary » More detailed page

PNP (purine nucleoside phosphorylase) C Show summary » More detailed page

XDH (xanthine dehydrogenase) C Show summary » More detailed page

ribonucleotide reductase M1 (ribonucleotide reductase catalytic subunit M1) C Show summary » More detailed page

ribonucleotide reductase M2 (ribonucleotide reductase regulatory subunit M2) C Show summary » More detailed page

ribonucleotide reductase M2B (TP53 inducible) (ribonucleotide reductase regulatory TP53 inducible subunit M2B) C Show summary » More detailed page

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How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism. Accessed on 22/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=920.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.