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Target not currently curated in GtoImmuPdb
Target id: 2754
Nomenclature: ribonucleotide reductase regulatory TP53 inducible subunit M2B
Abbreviated Name: ribonucleotide reductase M2B (TP53 inducible)
Family: 1.17.4.1 Ribonucleoside-diphosphate reductases, Nucleoside synthesis and metabolism
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 351 | 8q22.3 | RRM2B | ribonucleotide reductase regulatory TP53 inducible subunit M2B | |
Mouse | - | 351 | 15 B3.1 | Rrm2b | ribonucleotide reductase M2 B (TP53 inducible) | |
Rat | - | 351 | 7q22 | Rrm2b | ribonucleotide reductase regulatory TP53 inducible subunit M2B |
Previous and Unofficial Names ![]() |
ribonucleotide reductase M2 B (TP53 inducible) |
Database Links ![]() |
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Alphafold | Q7LG56 (Hs), Q6PEE3 (Mm) |
BRENDA | 1.17.1.4 |
ChEMBL Target | CHEMBL3301398 (Hs) |
DrugBank Target | Q7LG56 (Hs) |
Ensembl Gene | ENSG00000048392 (Hs), ENSMUSG00000022292 (Mm), ENSRNOG00000025454 (Rn) |
Entrez Gene | 50484 (Hs), 382985 (Mm), 299976 (Rn) |
Human Protein Atlas | ENSG00000048392 (Hs) |
KEGG Enzyme | 1.17.1.4 |
KEGG Gene | hsa:50484 (Hs), mmu:382985 (Mm), rno:299976 (Rn) |
OMIM | 604712 (Hs) |
Pharos | Q7LG56 (Hs) |
RefSeq Nucleotide | NM_015713 (Hs), NM_199476 (Mm), NM_001130543 (Rn) |
RefSeq Protein | NP_056528 (Hs), NP_955770 (Mm), NP_001124015 (Rn) |
UniProtKB | Q7LG56 (Hs), Q6PEE3 (Mm) |
Wikipedia | RRM2B (Hs) |
Enzyme Reaction ![]() |
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Inhibitor Comments | ||
Please see the Inhibitors table on the More detailed page for RRM1, for information on approved drugs which may act via this protein. |
Clinically-Relevant Mutations and Pathophysiology ![]() |
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Nucleoside synthesis and metabolism: ribonucleotide reductase regulatory TP53 inducible subunit M2B. Last modified on 28/11/2018. Accessed on 10/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2754.