Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1010	21q22.11	GART	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Mouse	-	1010	16 53.18 cM	Gart	phosphoribosylglycinamide formyltransferase
Rat	-	-	11q11	Gart	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Previous and Unofficial Names

PGFT | PRGS | trifunctional purine biosynthetic protein adenosine-3 | phosphoribosylglycinamide formyltransferase

Database Links
Alphafold	P22102 (Hs), Q64737 (Mm)
BRENDA	2.1.2.2, 6.3.3.1, 6.3.4.13
CATH/Gene3D	3.30.1490.20, 3.40.50.170, 3.90.600.10, 3.90.650.10, 3.30.1330.10
ChEMBL Target	CHEMBL3972 (Hs), CHEMBL3690 (Mm)
DrugBank Target	P22102 (Hs)
Ensembl Gene	ENSG00000159131 (Hs), ENSMUSG00000022962 (Mm), ENSRNOG00000028292 (Rn)
Entrez Gene	2618 (Hs), 14450 (Mm), 288259 (Rn)
Human Protein Atlas	ENSG00000159131 (Hs)
KEGG Enzyme	2.1.2.2, 6.3.3.1, 6.3.4.13
KEGG Gene	hsa:2618 (Hs), mmu:14450 (Mm), rno:288259 (Rn)
OMIM	138440 (Hs)
Pharos	P22102 (Hs)
RefSeq Nucleotide	NM_000819 (Hs), NM_010256 (Mm), NM_001011899 (Rn)
RefSeq Protein	NP_000810 (Hs), NP_034386 (Mm), NP_001011899 (Rn)
UniProtKB	P22102 (Hs), Q64737 (Mm)
Wikipedia	GART (Hs)

Enzyme Reaction
EC Number: 2.1.2.2 EC Number: 6.3.3.1 EC Number: 6.3.4.13

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference pemetrexed Mm Inhibition 5.0 pKi 1 ⤷ pKi 5.0 (Ki 9.3x10-6 M) [1]