Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	351	8q22.3	RRM2B	ribonucleotide reductase regulatory TP53 inducible subunit M2B
Mouse	-	351	15 B3.1	Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)
Rat	-	351	7q22	Rrm2b	ribonucleotide reductase regulatory TP53 inducible subunit M2B

Previous and Unofficial Names

ribonucleotide reductase M2 B (TP53 inducible)

Database Links
Alphafold	Q7LG56 (Hs), Q6PEE3 (Mm)
BRENDA	1.17.1.4
ChEMBL Target	CHEMBL3301398 (Hs)
DrugBank Target	Q7LG56 (Hs)
Ensembl Gene	ENSG00000048392 (Hs), ENSMUSG00000022292 (Mm), ENSRNOG00000025454 (Rn)
Entrez Gene	50484 (Hs), 382985 (Mm), 299976 (Rn)
Human Protein Atlas	ENSG00000048392 (Hs)
KEGG Enzyme	1.17.1.4
KEGG Gene	hsa:50484 (Hs), mmu:382985 (Mm), rno:299976 (Rn)
OMIM	604712 (Hs)
Pharos	Q7LG56 (Hs)
RefSeq Nucleotide	NM_015713 (Hs), NM_199476 (Mm), NM_001130543 (Rn)
RefSeq Protein	NP_056528 (Hs), NP_955770 (Mm), NP_001124015 (Rn)
UniProtKB	Q7LG56 (Hs), Q6PEE3 (Mm)
Wikipedia	RRM2B (Hs)

Enzyme Reaction
EC Number: 1.17.1.4

Inhibitor Comments

Please see the Inhibitors table on the More detailed page for RRM1, for information on approved drugs which may act via this protein.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Mitochondrial DNA depletion syndrome 8A (encephalomyopathic type with renal tubulopathy); MTDPS8A Synonyms: Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy [Orphanet: ORPHA255235] OMIM: 612075 Orphanet: ORPHA255235
Disease:  Mitochondrial neurogastrointestinal encephalomyopathy Synonyms: Mitochondrial neurogastrointestinal encephalopathy syndrome, RRM2B-related [OMIM: 612075] OMIM: 612075 Orphanet: ORPHA298
Disease:  Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5 Synonyms: Autosomal dominant progressive external ophthalmoplegia [Orphanet: ORPHA254892] OMIM: 613077 Orphanet: ORPHA254892