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eukaryotic translation elongation factor 2

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Target not currently curated in GtoImmuPdb

Target id: 2756

Nomenclature: eukaryotic translation elongation factor 2

Family: Ribosomal factors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 858 19p13.3 EEF2 eukaryotic translation elongation factor 2
Mouse - 858 10 C1 Eef2 eukaryotic translation elongation factor 2
Rat - 858 7q11 Eef2 eukaryotic translation elongation factor 2
Gene and Protein Information Comments
The Antimalarial targets family provides information about P. falciparum eEF2.
Previous and Unofficial Names Click here for help
EEF-2 | polypeptidyl-tRNA translocase
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Inhibitor Comments
Denileukin diftitox is an immunotoxic inhibitor of EEF2 (elongation factor 2). EEF2 is the primary target of the diptheria toxin [2,4] liberated upon intracellular processing of the endocytically internalised drug [3]. Denileukin diftitox inhibits protein synthesis in IL-2 receptor +ve cells (human C91/PL T cells) with an IC50 of 0.01nM [1] but protein synthesis is not inhibited in IL-2 receptor -ve cells in the same study.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0002244 hematopoietic progenitor cell differentiation IEA
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Spinocerebellar ataxia 26; SCA26
OMIM: 609306
Orphanet: ORPHA101112

References

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1. Bacha P, Williams DP, Waters C, Williams JM, Murphy JR, Strom TB. (1988) Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein. J Exp Med, 167 (2): 612-22. [PMID:3126255]

2. Deng Q, Barbieri JT. (2008) Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins. Annu Rev Microbiol, 62: 271-88. [PMID:18785839]

3. Jørgensen R, Merrill AR, Yates SP, Marquez VE, Schwan AL, Boesen T, Andersen GR. (2005) Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry. Nature, 436 (7053): 979-84. [PMID:16107839]

4. Jørgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Merrill AR. (2008) Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae. J Biol Chem, 283 (16): 10671-8. [PMID:18276581]

How to cite this page

Ribosomal factors: eukaryotic translation elongation factor 2. Last modified on 11/03/2019. Accessed on 14/06/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2756.