Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	858	11q23.2	NCAM1	neural cell adhesion molecule 1
Mouse	1	1115	9 26.83 cM	Ncam1	neural cell adhesion molecule 1
Rat	1	858	8q23	Ncam1	neural cell adhesion molecule 1
Gene and Protein Information Comments
Several isoforms of human CD56 have been identified. The longest protein, isoform 5, is listed in the table above. The Entrez gene; 4684 and Uniprot: P13591 records have further details of all of the isoforms currently identified. We also list the longest isoform (3) of the mouse CD56 protein (Entrez Gene, Uniprot P13595).

Database Links
Alphafold	P13591 (Hs), P13595 (Mm), P13596 (Rn)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL3712938 (Hs)
Ensembl Gene	ENSG00000149294 (Hs), ENSMUSG00000039542 (Mm), ENSRNOG00000031890 (Rn)
Entrez Gene	4684 (Hs), 17967 (Mm), 24586 (Rn)
Human Protein Atlas	ENSG00000149294 (Hs)
KEGG Gene	hsa:4684 (Hs), mmu:17967 (Mm), rno:24586 (Rn)
OMIM	116930 (Hs)
Pharos	P13591 (Hs)
RefSeq Nucleotide	NM_001242607 (Hs), NM_001113204 (Mm), NM_031521 (Rn)
RefSeq Protein	NP_001229536 (Hs), NP_001106675 (Mm), NP_113709 (Rn)
UniProtKB	P13591 (Hs), P13595 (Mm), P13596 (Rn)
Wikipedia	NCAM1 (Hs)

Immunopharmacology Comments

CD56 is expressed by neurons, glia, skeletal muscle and natural killer (NK) cells. The CD56bright NK cell subset, predominantly present in secondary lymphoid tissues, are capable of high levels of cytokine production, are enriched at inflammatory sites [1], and may have immunoregulatory function [2].

Cell Type Associations

Immuno Cell Type:  Natural killer cells Cell Ontology Term:   CD16-negative, CD56-bright natural killer cell, human (CL:0000938)

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Barrier integrity

General Comments
CD56 is used as an immunohistochemical marker for neuroendocrine tumours.