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neural cell adhesion molecule 1 (CD56)

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2769

Nomenclature: neural cell adhesion molecule 1 (CD56)

Abbreviated Name: NCAM1

Family: CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 858 11q23.2 NCAM1 neural cell adhesion molecule 1
Mouse 1 1115 9 26.83 cM Ncam1 neural cell adhesion molecule 1
Rat 1 858 8q23 Ncam1 neural cell adhesion molecule 1
Gene and Protein Information Comments
Several isoforms of human CD56 have been identified. The longest protein, isoform 5, is listed in the table above. The Entrez gene; 4684 and Uniprot: P13591 records have further details of all of the isoforms currently identified. We also list the longest isoform (3) of the mouse CD56 protein (Entrez Gene, Uniprot P13595).
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
CD56 is expressed by neurons, glia, skeletal muscle and natural killer (NK) cells. The CD56bright NK cell subset, predominantly present in secondary lymphoid tissues, are capable of high levels of cytokine production, are enriched at inflammatory sites [1], and may have immunoregulatory function [2].
Cell Type Associations
Immuno Cell Type:  Natural killer cells
Cell Ontology Term:   CD16-negative, CD56-bright natural killer cell, human (CL:0000938)
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Barrier integrity
General Comments
CD56 is used as an immunohistochemical marker for neuroendocrine tumours.


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1. Dalbeth N, Gundle R, Davies RJ, Lee YC, McMichael AJ, Callan MF. (2004) CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. J Immunol, 173 (10): 6418-26. [PMID:15528382]

2. Poli A, Michel T, Thérésine M, Andrès E, Hentges F, Zimmer J. (2009) CD56bright natural killer (NK) cells: an important NK cell subset. Immunology, 126 (4): 458-65. [PMID:19278419]

How to cite this page

CD molecules: neural cell adhesion molecule 1 (CD56). Last modified on 06/02/2017. Accessed on 20/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,