reticulon 4 | Reticulons and associated proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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reticulon 4

Target not currently curated in GtoImmuPdb

Target id: 2838

Nomenclature: reticulon 4

Family: Reticulons and associated proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 2 1192 2p16.1 RTN4 reticulon 4 2
Mouse 2 1162 11 A3.3 Rtn4 reticulon 4
Rat 2 1163 14q22 Rtn4 reticulon 4
Gene and Protein Information Comments
Human reticulon 4 has three reported alternatively spliced isoforms, RTN4A, -4B, and -4C (aka NOGO-A, -B and -C). The longest, and canonical sequence is RTN4A with 1192 amino acids. RTN4B lacks an in-frame segment of the coding region compared to RTN4A and is only 373 amino acids long. RTN4C differs from RTN4A in its 5' UTR and 5' coding region, resulting in a shorter protein (199 amino acids) with a distinct N-terminus. Similarly, the mouse gene is also alternatively spliced resulting in several protein isoforms. The longest is Rtn4A which is shown in the table above. Thus far only one rat Rtn4 isoform is reported.
Previous and Unofficial Names
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Antibody Sp. Action Value Parameter Reference
ozanezumab Hs Binding 9.2 pKd 1
pKd 9.2 (Kd 6.4x10-10 M) [1]
Description: Binding dissociation constant for clone H28L16.
Antibody Comments
The binding dissociation constant for ozanezumab is for binding to the RTN4A (NOGO-A) isoform.


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1. Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. (2007) Immunoglobulins. Patent number: US8362208. Assignee: Glaxo Group Ltd , Clegg SJ, Ellis JH, Germaschewski V, Hamblin PA, Kopsidas G, Mcadam R, Prinjha RK. Priority date: 16/12/2005. Publication date: 29/11/2007.

2. Yang J, Yu L, Bi AD, Zhao SY. (2000) Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping. Cytogenet. Cell Genet., 88 (1-2): 101-2. [PMID:10773680]

How to cite this page

Reticulons and associated proteins: reticulon 4. Last modified on 11/12/2018. Accessed on 24/10/2019. IUPHAR/BPS Guide to PHARMACOLOGY,