Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	2	1192	2p16.1	RTN4	reticulon 4	2
Mouse	2	1162	11 A3.3	Rtn4	reticulon 4
Rat	2	1163	14q22	Rtn4	reticulon 4
Gene and Protein Information Comments
Human reticulon 4 has three reported alternatively spliced isoforms, RTN4A, -4B, and -4C (aka NOGO-A, -B and -C). The longest, and canonical sequence is RTN4A with 1192 amino acids. RTN4B lacks an in-frame segment of the coding region compared to RTN4A and is only 373 amino acids long. RTN4C differs from RTN4A in its 5' UTR and 5' coding region, resulting in a shorter protein (199 amino acids) with a distinct N-terminus. Similarly, the mouse gene is also alternatively spliced resulting in several protein isoforms. The longest is Rtn4A which is shown in the table above. Thus far only one rat Rtn4 isoform is reported.

Previous and Unofficial Names

NOGO | NSP-CL | RTN4-XL | ASY

Database Links
Alphafold	Q9NQC3 (Hs), Q99P72 (Mm), Q9JK11 (Rn)
ChEMBL Target	CHEMBL3712895 (Hs)
Ensembl Gene	ENSG00000115310 (Hs), ENSMUSG00000020458 (Mm), ENSRNOG00000004621 (Rn)
Entrez Gene	57142 (Hs), 68585 (Mm), 83765 (Rn)
Human Protein Atlas	ENSG00000115310 (Hs)
KEGG Gene	hsa:57142 (Hs), mmu:68585 (Mm), rno:83765 (Rn)
OMIM	604475 (Hs)
Pharos	Q9NQC3 (Hs)
RefSeq Nucleotide	NM_007008 (Hs), NM_020532 (Hs), NM_153828 (Hs), NM_194052 (Mm), NM_194054 (Mm), NM_024226 (Mm), NM_031831 (Rn)
RefSeq Protein	NP_065393 (Hs), NP_722550 (Hs), NP_008939 (Hs), NP_077188 (Mm), NP_918941 (Mm), NP_918943 (Mm), NP_114019 (Rn)
UniProtKB	Q9NQC3 (Hs), Q99P72 (Mm), Q9JK11 (Rn)
Wikipedia	RTN4 (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference ozanezumab Hs Binding 9.2 pKd 1 ⤷ pKd 9.2 (Kd 6.4x10-10 M) [1] Description: Binding dissociation constant for clone H28L16.
Antibody Comments
The binding dissociation constant for ozanezumab is for binding to the RTN4A (NOGO-A) isoform.

Immuno Process Associations

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0034165 positive regulation of toll-like receptor 9 signaling pathway ISS

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 3 GO processes GO:0002523 leukocyte migration involved in inflammatory response ISS GO:1902624 positive regulation of neutrophil migration ISS GO:1905523 positive regulation of macrophage migration ISS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 2 GO processes GO:0034165 positive regulation of toll-like receptor 9 signaling pathway ISS GO:0060907 positive regulation of macrophage cytokine production ISS

Immuno Process:  Immune regulation GO Annotations:  Associated to 4 GO processes GO:0034165 positive regulation of toll-like receptor 9 signaling pathway ISS GO:0060907 positive regulation of macrophage cytokine production ISS GO:1902624 positive regulation of neutrophil migration ISS GO:1905523 positive regulation of macrophage migration ISS

Immuno Process:  Inflammation GO Annotations:  Associated to 4 GO processes GO:0002523 leukocyte migration involved in inflammatory response ISS GO:0034165 positive regulation of toll-like receptor 9 signaling pathway ISS GO:1902624 positive regulation of neutrophil migration ISS GO:1905523 positive regulation of macrophage migration ISS