lysyl oxidase like 2 | Lysyl oxidases | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

lysyl oxidase like 2

Target not currently curated in GtoImmuPdb

Target id: 2853

Nomenclature: lysyl oxidase like 2

Family: Lysyl oxidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 774 8p21.3 LOXL2 lysyl oxidase like 2
Mouse - 776 14 D2 Loxl2 lysyl oxidase-like 2
Rat - 776 15p11 Loxl2 lysyl oxidase-like 2
Previous and Unofficial Names
LOR2 | WS9-14 | protein-lysine 6-oxidase | lysyl oxidase homolog 2 | lysyl oxidase-like 2
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Description Reaction Reference
Reaction is required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices. peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2 1

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
simtuzumab Hs Inhibition 7.2 pKi 2
pKi 7.2 (Ki 6.7x10-8 M) [2]


Show »

1. Harris ED, Gonnerman WA, Savage JE, O'Dell BL. (1974) Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta. Biochim. Biophys. Acta, 341 (2): 332-44. [PMID:4838158]

2. Smith V, Ogg S, Van Vlasselaer P, Barry VE, Marshall D, Holzer AK, Rodriguez H, Oyasu M, McCauley SA, Garcia CA et al.. (2013) LOX and LOXL2 inhibitors and uses thereof. Patent number: US8461303 B2. Assignee: Gilead Biologics, Inc.. Priority date: 02/08/2007. Publication date: 11/06/2013.

How to cite this page Lysyl oxidases: lysyl oxidase like 2. Last modified on 29/01/2016. Accessed on 18/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,