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notch receptor 2

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Target not currently curated in GtoImmuPdb

Target id: 2859

Nomenclature: notch receptor 2

Family: Notch receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 2471 1p12 NOTCH2 notch receptor 2
Mouse 1 2473 3 42.42 cM Notch2 notch 2
Rat 1 2471 2q34 Notch2 notch receptor 2
Previous and Unofficial Names Click here for help
notch 2 | "Notch homolog 2 (Drosophila)
Database Links Click here for help
Alphafold Q04721 (Hs), O35516 (Mm), Q9QW30 (Rn)
CATH/Gene3D 1.25.40.20
ChEMBL Target CHEMBL3407320 (Hs)
Ensembl Gene ENSG00000134250 (Hs), ENSMUSG00000027878 (Mm), ENSRNOG00000018835 (Rn)
Entrez Gene 4853 (Hs), 18129 (Mm), 29492 (Rn)
Human Protein Atlas ENSG00000134250 (Hs)
KEGG Gene hsa:4853 (Hs), mmu:18129 (Mm), rno:29492 (Rn)
OMIM 600275 (Hs)
Pharos Q04721 (Hs)
RefSeq Nucleotide NM_024408 (Hs), NM_010928 (Mm), NM_024358 (Rn)
RefSeq Protein NP_077719 (Hs), NP_035058 (Mm), NP_077334 (Rn)
UniProtKB Q04721 (Hs), O35516 (Mm), Q9QW30 (Rn)
Wikipedia NOTCH2 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
Jagged2 {Sp: Human} Peptide Mm Activation - - 2
⤷ [2]
Description: Determined as binding to Notch2 on the surface of BaF3 cells
Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
tarextumab Peptide Click here for species-specific activity table Hs Binding >10.0 pKd 1
⤷ pKd >10.0 (Kd <1x10-10 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  B cell (activation)
Immuno Process:  Immune system development
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  Cytokine production & signalling
Immuno Process:  Tissue repair
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Alagille syndrome 2; ALGS2
Synonyms: Alagille syndrome [Disease Ontology: DOID:9245]
Alagille syndrome due to a NOTCH2 point mutation [Orphanet: ORPHA261629]
Disease Ontology: DOID:9245
OMIM: 610205
Orphanet: ORPHA261629
Disease:  Hajdu-Cheney syndrome; HJCYS
Synonyms: Acroosteolysis dominant type [Orphanet: ORPHA955]
Disease Ontology: DOID:2736
OMIM: 102500
Orphanet: ORPHA955

References

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1. Gurney AL, Hoey TC, van der Horst ETH, Sato AK, Liu YC, Bruhns MF, Lewicki JA. (2012) Antibodies to notch receptors. Patent number: US8226943 B2. Assignee: Oncomed Pharmaceuticals, Inc.. Priority date: 08/07/2008. Publication date: 24/07/2012.

2. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H. (2000) Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol, 20 (18): 6913-22. [PMID:10958687]

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