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Fc fragment of IgE receptor Ia

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2933

Nomenclature: Fc fragment of IgE receptor Ia

Abbreviated Name: FCεR1α

Family: Fc epsilon receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 257 1q23.2 FCER1A Fc epsilon receptor Ia
Mouse 1 250 1 80.33 cM Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide
Rat 1 245 13q24 Fcer1a Fc epsilon receptor Ia
Previous and Unofficial Names Click here for help
Fc receptor, IgE, high affinity I, alpha polypeptide | Fc receptor
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

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Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IgE heavy chain Peptide Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Binding 10.0 pKd
pKd 10.0 (Kd 1x10-10 M)
Immunopharmacology Comments
The product of the FCεR1A gene is a single-pass type I membrane protein that is a high-affinity receptor for immunoglobulin E (IgE). It is the ligand binding subunit of the tetrameric FCεRI, exhibiting a Kd of ~0.1nM.
Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   basophil (CL:0000767)
eosinophil (CL:0000771)
Immuno Cell Type:  Macrophages & monocytes
Comment:  Langerhans cells
Immuno Cell Type:  Mast cells
Immuno Process Associations
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  B cell (activation)
Immuno Process:  Cytokine production & signalling
Immuno Process:  Inflammation
Immuno Process:  T cell (activation)

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor Ia. Last modified on 08/05/2017. Accessed on 28/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,