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target has curated data in GtoImmuPdb
Target id: 2933
Nomenclature: Fc fragment of IgE receptor Ia
Abbreviated Name: FCεR1α
Family: Fc epsilon receptors
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 257 | 1q23.2 | FCER1A | Fc epsilon receptor Ia | |
Mouse | 1 | 250 | 1 80.33 cM | Fcer1a | Fc receptor, IgE, high affinity I, alpha polypeptide | |
Rat | 1 | 245 | 13q24 | Fcer1a | Fc epsilon receptor Ia |
Previous and Unofficial Names |
Fc receptor, IgE, high affinity I, alpha polypeptide | Fc receptor |
Database Links | |
Alphafold | P12319 (Hs), P20489 (Mm), P12371 (Rn) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL2248 (Hs) |
Ensembl Gene | ENSG00000179639 (Hs), ENSMUSG00000005339 (Mm), ENSRNOG00000009177 (Rn) |
Entrez Gene | 2205 (Hs), 14125 (Mm), 25047 (Rn) |
Human Protein Atlas | ENSG00000179639 (Hs) |
KEGG Gene | hsa:2205 (Hs), mmu:14125 (Mm), rno:25047 (Rn) |
OMIM | 47140 (Hs) |
Pharos | P12319 (Hs) |
RefSeq Nucleotide | NM_002001 (Hs), NM_010184 (Mm), NM_012724 (Rn) |
RefSeq Protein | NP_001992 (Hs), NP_034314 (Mm), NP_036856 (Rn) |
UniProtKB | P12319 (Hs), P20489 (Mm), P12371 (Rn) |
Wikipedia | FCER1A (Hs) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Immunopharmacology Comments |
The product of the FCεR1A gene is a single-pass type I membrane protein that is a high-affinity receptor for immunoglobulin E (IgE). It is the ligand binding subunit of the tetrameric FCεRI, exhibiting a Kd of ~0.1nM. |
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Fc epsilon receptors: Fc fragment of IgE receptor Ia. Last modified on 08/05/2017. Accessed on 07/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2933.