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membrane spanning 4-domains A2

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2936

Nomenclature: membrane spanning 4-domains A2

Abbreviated Name: FCεR1β

Family: Fc epsilon receptors

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 244 11q12.1 MS4A2 membrane spanning 4-domains A2
Mouse 4 235 19 8.46 cM Ms4a2 membrane-spanning 4-domains, subfamily A, member 2
Rat 4 243 1q43 Ms4a2 membrane spanning 4-domains A2
Gene and Protein Information Comments
The human MS4A2 gene produces two protein isoforms: isoform 1 (244aa) that traffics to the cytoplasmic membrane and isoform 3 (199aa) that triffics preferentially to the nuclear membrane. Four mouse protein isoforms are predicted.
Previous and Unofficial Names Click here for help
membrane-spanning 4-domains, subfamily A, member 2 | membrane-spanning 4-domains | APY | FCεR1β | FCεRIβ | IGEL | IGER
Database Links Click here for help
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Immunopharmacology Comments
The protein product of the MS4A2 gene is the β subunit of the FCεRI. It has commonly known as FCER1B. The IgE-receptor (FCεRI), is a tetramer composed of an α, β, and 2 disulfide-linked γ chains expressed on the surface of mast cells and basophils that is crucial for mediating the allergic response. It has been suggested that cytoplasmic FCER1B that is not associated with FCεRI complexes may act as a negative regulator of the signalling pathway to degranulation by sequestering important signalling partners such as the Lyn tyrosine kinase [1].
Immuno Process Associations
Immuno Process:  Immune regulation
Immuno Process:  Cellular signalling
Immuno Process:  Inflammation
Immuno Process:  Cytokine production & signalling


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1. Okayama Y, Matsuda A, Kashiwakura JI, Sasaki-Sakamoto T, Nunomura S, Shimokawa T, Yamaguchi K, Takahashi S, Ra C. (2014) Highly expressed cytoplasmic FcεRIβ in human mast cells functions as a negative regulator of the FcRγ-mediated cell activation signal. Clin Exp Allergy, 44 (2): 238-49. [PMID:24118172]

How to cite this page

Fc epsilon receptors: membrane spanning 4-domains A2. Last modified on 01/05/2017. Accessed on 21/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY,