Top ▲

MTB polyketide synthase Pks13

Click here for help

Target not currently curated in GtoImmuPdb

Target id: 2950

Nomenclature: MTB polyketide synthase Pks13

Family: Other anti-infective targets

Database Links Click here for help
ChEMBL Target
UniProtKB

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
TAM16 Small molecule or natural product Primary target of this compound Ligand has a PDB structure TB Inhibition 6.7 pIC50 1
pIC50 6.7 (IC50 1.9x10-7 M) [1]
General Comments
FAAL32-Pks13 polyketide synthase catalyzes the condensation reaction, which produces α-alkyl β-ketoacids, direct precursors of mycolic acids. This function is carried out by its thioesterase-like domain as a unique mechanism to transfer polyketide synthase products in mycobacteria, hence the focus on this as a drug target [2].

References

Show »

1. Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R et al.. (2017) Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell, 170 (2): 249-259.e25. [PMID:28669536]

2. Gavalda S, Bardou F, Laval F, Bon C, Malaga W, Chalut C, Guilhot C, Mourey L, Daffé M, Quémard A. (2014) The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria. Chem Biol, 21 (12): 1660-9. [PMID:25467124]

How to cite this page

Other anti-infective targets: MTB polyketide synthase Pks13. Last modified on 30/01/2018. Accessed on 28/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2950.