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leukocyte associated immunoglobulin like receptor 1 (CD305)

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2974

Nomenclature: leukocyte associated immunoglobulin like receptor 1 (CD305)

Abbreviated Name: LAIR1

Family: CD molecules

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 287 19q13.42 LAIR1 leukocyte associated immunoglobulin like receptor 1
Mouse 1 263 7 2.31 cM Lair1 leukocyte-associated Ig-like receptor 1
Rat 1 263 1q21 Lair1 leukocyte-associated immunoglobulin-like receptor 1
Gene and Protein Information Comments
Multiple transcript variants encoding different isoforms have been found for the human and mouse genes. We provide the RefSeqs and gene/protein information for isoform 1 (Hs) and isoform a (Mm)..
Previous and Unofficial Names Click here for help
Lair-1 | leukocyte-associated Ig-like receptor 1 | leukocyte-associated immunoglobulin-like receptor 1
Database Links Click here for help
Alphafold
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
LAIR1 has been identified as a potential molecular receptor for Plasmodium falciparum-coded proteins that are expressed by infected host erythrocytes. Interaction of these parasite RIFIN proteins (encoded by rif genes) and inhibitory leucocyte receptors such as LAIR1 may mediate parasite-driven evasion of the host's immune system [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002250 adaptive immune response IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0050776 regulation of immune response TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0043312 neutrophil degranulation TAS
General Comments
LAIR1 (CD305) is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells.

References

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1. Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S et al.. (2017) Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Nature, 552 (7683): 101-105. [PMID:29186116]

How to cite this page

CD molecules: leukocyte associated immunoglobulin like receptor 1 (CD305). Last modified on 28/07/2020. Accessed on 13/08/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2974.