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target has curated data in GtoImmuPdb
Target id: 2988
Nomenclature: melanoma cell adhesion molecule
Systematic Nomenclature: CD146
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 646 | 11q23.3 | MCAM | melanoma cell adhesion molecule | 4-5 |
| Mouse | 1 | 648 | 9 A5.1 | Mcam | melanoma cell adhesion molecule | |
| Rat | 1 | 648 | 8q22 | Mcam | melanoma cell adhesion molecule | |
| Gene and Protein Information Comments | ||||||
| Shorter isoforms from the rat and mouse genes (both 606 aa) have been identified. | ||||||
| Previous and Unofficial Names |
| CD146 | Gicerin | MUC18 |
| Database Links |
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| Alphafold | P43121 (Hs), Q8R2Y2 (Mm), Q9EPF2 (Rn) |
| ChEMBL Target | CHEMBL3712863 (Hs) |
| Ensembl Gene | ENSG00000076706 (Hs), ENSMUSG00000032135 (Mm), ENSRNOG00000007726 (Rn) |
| Entrez Gene | 4162 (Hs), 84004 (Mm), 78967 (Rn) |
| Human Protein Atlas | ENSG00000076706 (Hs) |
| KEGG Gene | hsa:4162 (Hs), mmu:84004 (Mm), rno:78967 (Rn) |
| OMIM | 155735 (Hs) |
| Pharos | P43121 (Hs) |
| RefSeq Nucleotide | NM_006500 (Hs), NM_023061 (Mm), NM_023983 (Rn), NM_001034009 (Rn) |
| RefSeq Protein | NP_006491 (Hs), NP_075548 (Mm), NP_076473 (Rn), NP_001029181 (Rn) |
| UniProtKB | P43121 (Hs), Q8R2Y2 (Mm), Q9EPF2 (Rn) |
| Wikipedia | MCAM (Hs) |
Download all structure-activity data for this target as a CSV file 
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| Immunopharmacology Comments |
| In addition to its tumourigenic activity, MCAM is implicated in the development of human autoimmune diseases. A subset of peripheral effector memory phenotype T cells expressing MCAM have been identified in elevated numbers in patients with autoimmune diseases, where they appear to be the major producers of IL-17, a key mediator in autoimmune diseases [2]. MCAM on the surface of Th17 cells facilitates their interaction with the vasculature. MCAM is the target of the investigational monoclonal antibody imaprelimab (PRX-003) that was developed as an anti-psoriasis therapy. |
| General Comments |
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MCAM is a cell adhesion molecule that has been implicated in tumour growth and metastasis [1,6-7]. In addition to its immunoglobulin (Ig) C2-set domain the MCAM protein contains an Ig-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590. |
1. Colomb F, Wang W, Simpson D, Zafar M, Beynon R, Rhodes JM, Yu LG. (2017) Galectin-3 interacts with the cell-surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells. J Biol Chem, 292 (20): 8381-8389. [PMID:28364041]
2. Dagur PK, McCoy Jr JP. (2015) Endothelial-binding, proinflammatory T cells identified by MCAM (CD146) expression: Characterization and role in human autoimmune diseases. Autoimmun Rev, 14 (5): 415-22. [PMID:25595133]
3. Flanagan K, Baker J, Yednock TA. (2014) Anti-mcam antibodies and associated methods of use. Patent number: WO2014039975. Assignee: Neotope Biosciences Limited. Priority date: 10/09/2012. Publication date: 13/03/2012.
4. Kuske MD, Johnson JP. (1999) Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. Cytogenet Cell Genet, 87 (3-4): 258. [PMID:10702685]
5. Lehmann JM, Riethmüller G, Johnson JP. (1989) MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci USA, 86 (24): 9891-5. [PMID:2602381]
6. Sechler M, Parrish JK, Birks DK, Jedlicka P. (2017) The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis. Oncogene, 36 (29): 4150-4160. [PMID:28319067]
7. Wang J, Tang X, Weng W, Qiao Y, Lin J, Liu W, Liu R, Ma L, Yu W, Yu Y et al.. (2015) The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. Oncogene, 34 (47): 5781-95. [PMID:25728681]
Immunoglobulin C2-set domain-containing proteins: melanoma cell adhesion molecule. Last modified on 07/08/2019. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2988.
