dual oxidase 2 | NADPH oxidases | IUPHAR/BPS Guide to PHARMACOLOGY

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dual oxidase 2

Target not currently curated in GtoImmuPdb

Target id: 2999

Nomenclature: dual oxidase 2

Abbreviated Name: DUOX2

Family: NADPH oxidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 1548 15q21.1 DUOX2 dual oxidase 2 2-3
Mouse - 1545 Chromosome 2, 60.61 cM; 2 E5 Duox2 dual oxidase 2
Rat 7 1517 3q35 Duox2 dual oxidase 2
Previous and Unofficial Names
dual oxidase-like domains 2 | LNOX2 | NADPH oxidase/peroxidase DUOX2 | NADPH thyroid oxidase 2 | P138(TOX) | THOX2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.6.3.1
Description Reaction Reference
Generation of hydrogen peroxide NAD(P)H + O2 <=> NAD(P)+ + H2O2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
NSC 780521 Hs Inhibition 6.1 pIC50 6
pIC50 6.1 (IC50 7.73x10-7 M) [6]
Description: Inhibition of hydrogen peroxide formation in HEK293 cells expressing DUOX2/DUOXA2.
Tissue Distribution
DUOX2 is the main DUOX isoform expressed in the gastrointestinal tract- expressed most prominently within the colon epithelium at the tip of intestinal villi and within rectal glands.
Species:  Human
Technique: 
References:  4-5,7
Gene Expression and Pathophysiology Comments
Missense mutations in DUOX2 that cause diminished enzymatic function have been identified in patients with hypothyroidism [1], confirming the role of this enzyme isoform in thyroid hormone production.

References

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1. De Deken X, Corvilain B, Dumont JE, Miot F. (2014) Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling. Antioxid. Redox Signal., 20 (17): 2776-93. [PMID:24161126]

2. De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, Miot F. (2000) Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J. Biol. Chem., 275 (30): 23227-33. [PMID:10806195]

3. Dupuy C, Ohayon R, Valent A, Noël-Hudson MS, Dème D, Virion A. (1999) Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J. Biol. Chem., 274 (52): 37265-9. [PMID:10601291]

4. El Hassani RA, Benfares N, Caillou B, Talbot M, Sabourin JC, Belotte V, Morand S, Gnidehou S, Agnandji D, Ohayon R et al.. (2005) Dual oxidase2 is expressed all along the digestive tract. Am. J. Physiol. Gastrointest. Liver Physiol., 288 (5): G933-42. [PMID:15591162]

5. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL. (2003) Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J., 17 (11): 1502-4. [PMID:12824283]

6. Lu J, Risbood P, Kane Jr CT, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A et al.. (2017) Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases. Biochem. Pharmacol., 143: 25-38. [PMID:28709950]

7. Sommer F, Bäckhed F. (2015) The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium. Mucosal Immunol, 8 (2): 372-9. [PMID:25160818]

How to cite this page

NADPH oxidases: dual oxidase 2. Last modified on 01/05/2018. Accessed on 17/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2999.