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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 7 | 765 | 15q23 | NOX5 | NADPH oxidase 5 | 2 |
Gene and Protein Information Comments | ||||||
There are no rat or mouse orthologues of the human NOX5 gene. Variant 1 (NOX5 gamma, or v3) encodes isoform 1 which is the longest protein product dervived from this gene. Two shorter isoforms are also encoded by NOX5. |
Previous and Unofficial Names ![]() |
NADPH oxidase, EF-hand calcium binding domain 5 |
Database Links ![]() |
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Alphafold | Q96PH1 (Hs) |
ChEMBL Target | CHEMBL1926497 (Hs) |
Ensembl Gene | ENSG00000255346 (Hs) |
Entrez Gene | 79400 (Hs) |
Human Protein Atlas | ENSG00000255346 (Hs) |
KEGG Gene | hsa:79400 (Hs) |
OMIM | 606572 (Hs) |
Pharos | Q96PH1 (Hs) |
RefSeq Nucleotide | NM_024505 (Hs) |
RefSeq Protein | NP_078781 (Hs) |
UniProtKB | Q96PH1 (Hs) |
Wikipedia | NOX5 (Hs) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C et al.. (2012) Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology, 56 (6): 2316-27. [PMID:22806357]
2. Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, Krause KH. (2001) A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem, 276 (40): 37594-601. [PMID:11483596]
3. Gaggini F, Laleu B, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F et al.. (2011) Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem, 19 (23): 6989-99. [PMID:22041175]
4. Lu J, Risbood P, Kane Jr CT, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A et al.. (2017) Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases. Biochem Pharmacol, 143: 25-38. [PMID:28709950]