NADPH oxidase 5 | NADPH oxidases | IUPHAR/BPS Guide to PHARMACOLOGY

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NADPH oxidase 5

Target not currently curated in GtoImmuPdb

Target id: 3005

Nomenclature: NADPH oxidase 5

Abbreviated Name: NOX5

Family: NADPH oxidases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 765 15q23 NOX5 NADPH oxidase 5 2
Gene and Protein Information Comments
There are no rat or mouse orthologues of the human NOX5 gene. Variant 1 (NOX5 gamma, or v3) encodes isoform 1 which is the longest protein product dervived from this gene. Two shorter isoforms are also encoded by NOX5.
Previous and Unofficial Names
NADPH oxidase, EF-hand calcium binding domain 5
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GKT137831 Hs Inhibition 6.4 pKi 1
pKi 6.4 (Ki 4.1x10-7 M) [1]
compound 7c [PMID: 22041175] Hs Inhibition 6.4 pKi 3
pKi 6.4 (Ki 4.14x10-7 M) [3]
NSC 780521 Hs Inhibition 6.6 pIC50 4
pIC50 6.6 (IC50 2.29x10-7 M) [4]
Description: Inhibition of PMA-induced superoxide production by UACC-257 cells.

References

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1. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C et al.. (2012) Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Hepatology, 56 (6): 2316-27. [PMID:22806357]

2. Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, Krause KH. (2001) A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J. Biol. Chem., 276 (40): 37594-601. [PMID:11483596]

3. Gaggini F, Laleu B, Orchard M, Fioraso-Cartier L, Cagnon L, Houngninou-Molango S, Gradia A, Duboux G, Merlot C, Heitz F et al.. (2011) Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg. Med. Chem., 19 (23): 6989-99. [PMID:22041175]

4. Lu J, Risbood P, Kane Jr CT, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A et al.. (2017) Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases. Biochem. Pharmacol., 143: 25-38. [PMID:28709950]

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