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CD37 molecule

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 3010

Nomenclature: CD37 molecule

Abbreviated Name: CD37

Family: CD molecules, Tetraspanins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 281 19q13.33 CD37 CD37 molecule 14
Mouse - 303 7 B3; Ch 7, 29.20 cM Cd37 CD37 antigen
Rat 4 281 1q22 Cd37 CD37 molecule
Gene and Protein Information Comments
The human CD37 gene produces two transcript variants and two protein isoforms: isoform A is 281 aa, isoform B is shorter at its N-terminus and is 213 aa. The longest mouse protein isoform (1) is 303 aa, isoform 2 is 278 aa, and isoform 3 is 281 aa.
Previous and Unofficial Names Click here for help
CD37 antigen | tetraspanin 26 | TSPAN26
Database Links Click here for help
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
lilotomab Peptide Primary target of this compound Immunopharmacology Ligand Hs Binding 8.6 pKd 3
pKd 8.6 (Kd 2.7x10-9 M) [3]
Description: Binding affinity to CD37 on Daudi (human Burkitt's lymphoma) cells.
naratuximab emtansine Peptide Primary target of this compound Immunopharmacology Ligand Hs Binding 9.3 pEC50 5
pEC50 9.3 (EC50 5x10-10 M) [5]
Description: Binding affinity to CD37 antigen–positive cells as measured by flow cytometry.
otlertuzumab Peptide Primary target of this compound Immunopharmacology Ligand Hs Binding - - 10
Immunopharmacology Comments
CD37 is included in GtoImmuPdb as it is an immuno-oncology target that is being expoited for the development of novel therapeutics for the treatment of B cell malignancies, including non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) [5,9,12,15].
Cell Type Associations
Immuno Cell Type:  T cells
Comment:  CD37 expression by T cells and myeloid cells is lower than expression by mature B cells.
Immuno Cell Type:  B cells
Cell Ontology Term:   mature B cell (CL:0000785)
Comment:  CD37 is more highly expressed by mature B cells than by T cells or myeloid cells. It is not expressed by CD10+, CD34+ and CD34- B cell precursors in the bone marrow. Expression is lost in terminally differentiated plasma cells. CD37 is minimally detectable on T cells, monocytes and granulocytes, and is not expressed by natural killer (NK) cells, platelets or erythrocytes. CD37 is highly expressed by transformed mature B cell leukemia and lymphoma cells but not by myeloma cells.
References:  1,8,11
Physiological Consequences of Altering Gene Expression Click here for help
Cd37-deficiency in mice leads to spontaneous development of B cell lymphoma. Tumour development appears to be driven by constitutive activation of the IL-6 signaling pathway in a suppressor of cytokine signaling 3 (SOCS3)-dependent manner. Note that Cd37-negative mice show no overt changes in the development or cellular composition of lymphoid organs, despite the high level of Cd37 expression by cells of the immune system.
Species:  Mouse
References:  4,6
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Diffuse large B-cell lymphoma
Description: DLBCL is an aggressive lymphoproliferative malignancy that arises in the lymph nodes. It is the most common subtype of non-Hodgkin lymphoma in adults. DLBCL is classified as a rare disease.
Synonyms: DLBCL
Disease Ontology: DOID:0050745
Disease:  non-Hodgkin lymphoma
Description: A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma.
Disease Ontology: DOID:0060060
OMIM: 605027
References:  15
General Comments
The CD37 protein has 4 hydrophobic transmembrane domains, and it belongs to the tetraspanin (TSPAN) protein family (HGNC family ID 768) [2,13]. It is expressed solely by cells of the immune system, and is involved in the regulation of immune responses [7], cell-cell interactions, cell development, activation, growth and motility [2,13]. CD37 is found on normal and malignant B cells. It has been identified as a tumour suppressor that protects against B cell lymphomagenesis, an effect that is mediated by inhibiting the IL-6 pathway [4], and in support of this mechanism is the observation that in human lymphomas CD37 deficiency is a marker of poor prognosis [16].


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1. Barrena S, Almeida J, Yunta M, López A, Fernández-Mosteirín N, Giralt M, Romero M, Perdiguer L, Delgado M, Orfao A et al.. (2005) Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation. Leukemia, 19 (8): 1376-83. [PMID:15931266]

2. Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E. (2009) Lateral organization of membrane proteins: tetraspanins spin their web. Biochem J, 420 (2): 133-54. [PMID:19426143]

3. Dahle J, Repetto-Llamazares AH, Mollatt CS, Melhus KB, Bruland OS, Kolstad A, Larsen RH. (2013) Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma. Anticancer Res, 33 (1): 85-95. [PMID:23267131]

4. de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, Jabbar KJ, van den Brand M, van der Schaaf A, Elfrink S et al.. (2016) Tetraspanin CD37 protects against the development of B cell lymphoma. J Clin Invest, 126 (2): 653-66. [PMID:26784544]

5. Deckert J, Park PU, Chicklas S, Yi Y, Li M, Lai KC, Mayo MF, Carrigan CN, Erickson HK, Pinkas J et al.. (2013) A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies. Blood, 122 (20): 3500-10. [PMID:24002446]

6. Knobeloch KP, Wright MD, Ochsenbein AF, Liesenfeld O, Löhler J, Zinkernagel RM, Horak I, Orinska Z. (2000) Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions. Mol Cell Biol, 20 (15): 5363-9. [PMID:10891477]

7. Levy S, Shoham T. (2005) The tetraspanin web modulates immune-signalling complexes. Nat Rev Immunol, 5 (2): 136-48. [PMID:15688041]

8. Link MP, Bindl J, Meeker TC, Carswell C, Doss CA, Warnke RA, Levy R. (1986) A unique antigen on mature B cells defined by a monoclonal antibody. J Immunol, 137 (9): 3013-8. [PMID:3489782]

9. Pagel JM, Spurgeon SE, Byrd JC, Awan FT, Flinn IW, Lanasa MC, Eisenfeld AJ, Stromatt SC, Gopal AK. (2015) Otlertuzumab (TRU-016), an anti-CD37 monospecific ADAPTIR(™) therapeutic protein, for relapsed or refractory NHL patients. Br J Haematol, 168 (1): 38-45. [PMID:25146490]

10. Rafiq S, Siadak A, Butchar JP, Cheney C, Lozanski G, Jacob NK, Lapalombella R, McGourty J, Moledor M, Lowe R et al.. (2013) Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies. MAbs, 5 (5): 723-35. [PMID:23883821]

11. Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G. (1988) The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein. J Immunol, 140 (3): 905-14. [PMID:3257508]

12. Stathis A, Flinn IW, Madan S, Maddocks K, Freedman A, Weitman S, Zucca E, Munteanu MC, Lia Palomba M. (2018) Safety, tolerability, and preliminary activity of IMGN529, a CD37-targeted antibody-drug conjugate, in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: a dose-escalation, phase I study. Invest New Drugs, 36 (5): 869-876. [PMID:29453628]

13. van Deventer SJ, Dunlock VE, van Spriel AB. (2017) Molecular interactions shaping the tetraspanin web. Biochem Soc Trans, 45 (3): 741-750. [PMID:28620035]

14. Virtaneva KI, Angelisová P, Baumruker T, Horejsí V, Nevanlinna H, Schröder J. (1993) The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes. Immunogenetics, 37 (6): 461-5. [PMID:8436422]

15. Witkowska M, Smolewski P, Robak T. (2018) Investigational therapies targeting CD37 for the treatment of B-cell lymphoid malignancies. Expert Opin Investig Drugs, 27 (2): 171-177. [PMID:29323537]

16. Xu-Monette ZY, Li L, Byrd JC, Jabbar KJ, Manyam GC, Maria de Winde C, van den Brand M, Tzankov A, Visco C, Wang J et al.. (2016) Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma. Blood, 128 (26): 3083-3100. [PMID:27760757]

How to cite this page

CD molecules: CD37 molecule. Last modified on 05/11/2020. Accessed on 20/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,