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Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3

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Target not currently curated in GtoImmuPdb

Malaria Pharmacology Ligand  Target has curated data in GtoMPdb

Target id: 3076

Nomenclature: Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3

Abbreviated Name: PfCPSF3

Family: Other antimalarial targets

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 876 CPSF3 cleavage and polyadenylation specificity factor subunit 3, putative
Previous and Unofficial Names Click here for help
PfCPSF73 | PfCPSF-73
Database Links Click here for help
PlasmoDB
UniProtKB
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
AN3661 Small molecule or natural product PfK1 Parasite growth inhibition assay - - 7.7 pIC50 2
pIC50 7.7 (IC50 2x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 Small molecule or natural product PfFCR3 Parasite growth inhibition assay - - 7.5 pIC50 2
pIC50 7.5 (IC50 3x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 Small molecule or natural product PfDd2 Parasite growth inhibition assay - - 7.4 pIC50 2
pIC50 7.4 (IC50 3.9x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 Small molecule or natural product Pf3D7 Parasite growth inhibition assay - - 7.3 pIC50 2
pIC50 7.3 (IC50 5.2x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
AN3661 Small molecule or natural product PfHB3 Parasite growth inhibition assay - - 7.3 pIC50 2
pIC50 7.3 (IC50 5.6x10-8 M) [3H]-hypoxanthine incorporation [2]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
Cleavage and Polyadenylation Specificity Factor subunit 3 (CPSF3 or CPSF73) is a 73kDa subunit of the CPSF protein complex. This complex directs the 3' cleavage and polyadenylation reaction that is an essential step in eukaryotic mRNA processing. CPSF3 is a zinc-dependent endonuclease that cleaves the mRNA precursor downstream of the polyadenylation signal sequence [1].
P. falciparum CPSF3 (PfCPSF3) has been identified as a possible target for the benzoxaborole hit compound AN3661 and may have potential as a target for antimalarial drug development [2].

References

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1. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L. (2006) Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature, 444 (7121): 953-6. [PMID:17128255]

2. Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ et al.. (2017) A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun, 8: 14574. [PMID:28262680]

How to cite this page

Other antimalarial targets: Plasmodium falciparum cleavage and polyadenylation specificity factor subunit 3. Last modified on 08/03/2021. Accessed on 13/05/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3076.