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Target not currently curated in GtoImmuPdb
Target has curated data in GtoMPdb
Target id: 3091
Nomenclature: Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase beta
Abbreviated Name: PfPDEbeta
Family: Cyclic nucleotide turnover/signalling (Plasmodium spp.)
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Plasmodium falciparum 3D7 | - | 1139 | PDEbeta | 3',5'-cyclic nucleotide phosphodiesterase beta | ||
| Previous and Unofficial Names |
| PDEbeta | Pf3D7_13_v3:889,872..895,607(-) | MAL13P1.118 | PDEβ |
| Database Links |
|
| Alphafold | Q8I6Z7 (Pf3D7) |
| PlasmoDB | PF3D7_1321500 (Pf3D7) |
| UniProtKB | Q8I6Z7 (Pf3D7) |
| Malaria Pharmacology Comments |
| P. falciparum 3',5'-cyclic nucleotide phosphodiesterase beta (PfPDEbeta) hydrolyses both cyclic AMP and cyclic GMP and is essential during the asexual blood stage of the parasite lifecycle [1]. PfPDEbeta is a target "under consideration" in the Malaria Drug Accelerator (MalDA) portfolio [2]. |
1. Flueck C, Drought LG, Jones A, Patel A, Perrin AJ, Walker EM, Nofal SD, Snijders AP, Blackman MJ, Baker DA. (2019) Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. PLoS Biol, 17 (2): e3000154. [PMID:30794532]
2. Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK et al.. (2021) Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS Infect Dis, 7 (10): 2764-2776. [PMID:34523908]
Cyclic nucleotide turnover/signalling (Plasmodium spp.): Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase beta. Last modified on 13/12/2021. Accessed on 12/09/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3091.
