5-ht<sub>5b</sub> receptor | 5-Hydroxytryptamine receptors | IUPHAR/BPS Guide to PHARMACOLOGY

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5-ht5b receptor

Target not currently curated in GtoImmuPdb

Target id: 648

Nomenclature: 5-ht5b receptor

Family: 5-Hydroxytryptamine receptors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
class A G protein-coupled receptor: pseudogene in man
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - 2q14.1 HTR5BP 5-hydroxytryptamine receptor 5B, pseudogene
Mouse 7 - 1 63.0 cM Htr5b 5-hydroxytryptamine (serotonin) receptor 5B
Rat 7 - 13p12 Htr5b 5-hydroxytryptamine (serotonin) receptor 5B
Gene and Protein Information Comments
The human orthologue of the mouse 5-ht5b receptor is non-functional due to interruption of the gene by stop codons.
Previous and Unofficial Names
GPR134 | HTR5B | G protein-coupled receptor 134 | 5Ht5b | MR22 | serotonin receptor 5B | 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene
Database Links
Specialist databases
GPCRDB 5ht5b_mouse (Mm), 5ht5b_rat (Rn)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Natural/Endogenous Ligands
5-hydroxytryptamine

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]LSD Mm Full agonist 9.3 pKd 1
pKd 9.3 (Kd 4.7x10-10 M) [1]
[3H]5-CT Mm Full agonist - - 2
[2]

References

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1. Matthes H, Boschert U, Amlaiky N, Grailhe R, Plassat JL, Muscatelli F, Mattei MG, Hen R. (1993) Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol. Pharmacol., 43 (3): 313-9. [PMID:8450829]

2. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998) Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann. N. Y. Acad. Sci., 861: 85-90. [PMID:9928243]

Contributors

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