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Target not currently curated in GtoImmuPdb
Target id: 970
Nomenclature: Na-Cl symporter
Abbreviated Name: NCC
Systematic Nomenclature: SLC12A3
Family: SLC12 family of cation-coupled chloride transporters
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 12 | 1021 | 16q13 | SLC12A3 | solute carrier family 12 member 3 | 1 |
Mouse | 12 | 1002 | 8 46.46 cM | Slc12a3 | solute carrier family 12, member 3 | |
Rat | 12 | 1002 | 19p13-p12 | Slc12a3 | solute carrier family 12 member 3 |
Database Links | |
Specialist databases | |
Bioparadigms SLC Tables | SLC12A3 (Hs) |
RESOLUTE | SLC12A3 (Hs) |
Other databases | |
Alphafold | P55017 (Hs), P59158 (Mm), P55018 (Rn) |
ChEMBL Target | CHEMBL1876 (Hs) |
DrugBank Target | P55017 (Hs) |
Ensembl Gene | ENSG00000070915 (Hs), ENSMUSG00000031766 (Mm), ENSRNOG00000057072 (Rn) |
Entrez Gene | 6559 (Hs), 20497 (Mm), 54300 (Rn) |
Human Protein Atlas | ENSG00000070915 (Hs) |
KEGG Gene | hsa:6559 (Hs), mmu:20497 (Mm), rno:54300 (Rn) |
OMIM | 600968 (Hs) |
Orphanet | ORPHA118740 (Hs) |
Pharos | P55017 (Hs) |
UniProtKB | P55017 (Hs), P59158 (Mm), P55018 (Rn) |
Wikipedia | SLC12A3 (Hs) |
Stoichiometry | |
1 Na+ : 1 Cl- (in) |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Clinically-Relevant Mutations and Pathophysiology | ||||||||||||||
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1. Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, Ballabio A, Casari G. (1996) Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). Genomics, 35 (3): 486-93. [PMID:8812482]
2. Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vázquez N, Ellison DH, Gamba G. (2004) Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. Am J Physiol Renal Physiol, 287 (2): F195-203. [PMID:15068971]
SLC12 family of cation-coupled chloride transporters: Na-Cl symporter. Last modified on 01/04/2015. Accessed on 05/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=970.