Na-Cl symporter | SLC12 family of cation-coupled chloride transporters | IUPHAR/BPS Guide to PHARMACOLOGY

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Na-Cl symporter

Target not currently curated in GtoImmuPdb

Target id: 970

Nomenclature: Na-Cl symporter

Abbreviated Name: NCC

Systematic Nomenclature: SLC12A3

Family: SLC12 family of cation-coupled chloride transporters

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1021 16q13 SLC12A3 solute carrier family 12 member 3 1
Mouse - 1002 8 46.46 cM Slc12a3 solute carrier family 12, member 3
Rat - 1002 19p14-p12 Slc12a3 solute carrier family 12 member 3
Previous and Unofficial Names
Thiazide-sensitive sodium-chloride cotransporter | TSC | NCCT | solute carrier family 12 (sodium/chloride transporters), member 3 | solute carrier family 12 (sodium/chloride transporter), member 3 | solute carrier family 12
Database Links
Specialist databases
Bioparadigms SLC Tables SLC12A3 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
1 Na+ : 1 Cl- (in)

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cyclothiazide Hs Inhibition - -
chlorothiazide Hs Inhibition - -
hydrochlorothiazide Hs Inhibition - -
metolazone Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Gitelman syndrome
Disease Ontology: DOID:0050450
OMIM: 263800
Orphanet: ORPHA358
References:  2


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1. Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, Ballabio A, Casari G. (1996) Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). Genomics, 35 (3): 486-93. [PMID:8812482]

2. Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vázquez N, Ellison DH, Gamba G. (2004) Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. Am. J. Physiol. Renal Physiol., 287 (2): F195-203. [PMID:15068971]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Na-Cl symporter. Last modified on 01/04/2015. Accessed on 19/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,