bosutinib

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2
Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value (-log10) Parameter Value (nM) Parameter
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317L)-phosphorylated Hs Inhibitor Inhibition 10.5 pKd 0.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(Y253F)-phosphorylated Hs Inhibitor Inhibition 10.4 pKd 0.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(M351T)-phosphorylated Hs Inhibitor Inhibition 10.4 pKd 0.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(Q252H)-phosphorylated Hs Inhibitor Inhibition 10.4 pKd 0.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(E255K)-phosphorylated Hs Inhibitor Inhibition 10.3 pKd 0.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(H396P)-phosphorylated Hs Inhibitor Inhibition 10.2 pKd 0.1 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1-phosphorylated Hs Inhibitor Inhibition 10.2 pKd 0.1 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(H396P)-nonphosphorylated Hs Inhibitor Inhibition 10.2 pKd 0.1 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(Q252H)-nonphosphorylated Hs Inhibitor Inhibition 10.1 pKd 0.1 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317L)-nonphosphorylated Hs Inhibitor Inhibition 10.0 pKd 0.1 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1-nonphosphorylated Hs Inhibitor Inhibition 9.9 pKd 0.1 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317I)-phosphorylated Hs Inhibitor Inhibition 9.7 pKd 0.2 Kd
mitogen-activated protein kinase kinase kinase kinase 5 MAP4K5 Hs Inhibitor Inhibition 9.3 pKd 0.5 Kd
LCK proto-oncogene, Src family tyrosine kinase LCK Hs Inhibitor Inhibition 9.2 pKd 0.6 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(F317I)-nonphosphorylated Hs Inhibitor Inhibition 9.2 pKd 0.6 Kd
erb-b2 receptor tyrosine kinase 3 ERBB3 Hs Inhibitor Inhibition 9.1 pKd 0.8 Kd
SRC proto-oncogene, non-receptor tyrosine kinase SRC Hs Inhibitor Inhibition 9.0 pKd 1.0 Kd
cyclin G associated kinase GAK Hs Inhibitor Inhibition 8.9 pKd 1.3 Kd
fyn related Src family tyrosine kinase FRK Hs Inhibitor Inhibition 8.9 pKd 1.4 Kd
ABL proto-oncogene 2, non-receptor tyrosine kinase ABL2 Hs Inhibitor Inhibition 8.8 pKd 1.5 Kd
serine/threonine kinase 35 STK35 Hs Inhibitor Inhibition 8.7 pKd 2.0 Kd
mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Hs Inhibitor Inhibition 8.5 pKd 3.1 Kd
misshapen like kinase 1 MINK Hs Inhibitor Inhibition 8.5 pKd 3.2 Kd
BLK proto-oncogene, Src family tyrosine kinase BLK Hs Inhibitor Inhibition 8.5 pKd 3.3 Kd
HCK proto-oncogene, Src family tyrosine kinase HCK Hs Inhibitor Inhibition 8.5 pKd 3.4 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-phosphorylated Hs Inhibitor Inhibition 8.4 pKd 3.6 Kd
YES proto-oncogene 1, Src family tyrosine kinase YES Hs Inhibitor Inhibition 8.4 pKd 4.0 Kd
LYN proto-oncogene, Src family tyrosine kinase LYN Hs Inhibitor Inhibition 8.4 pKd 4.2 Kd
STE20 like kinase SLK Hs Inhibitor Inhibition 8.3 pKd 4.7 Kd
Bruton tyrosine kinase BTK Hs Inhibitor Inhibition 8.3 pKd 4.8 Kd
mitogen-activated protein kinase kinase kinase kinase 3 MAP4K3 Hs Inhibitor Inhibition 8.3 pKd 5.1 Kd
EPH receptor A3 EPHA3 Hs Inhibitor Inhibition 8.2 pKd 5.8 Kd
FGR proto-oncogene, Src family tyrosine kinase FGR Hs Inhibitor Inhibition 8.2 pKd 6.3 Kd
serine/threonine kinase 10 LOK Hs Inhibitor Inhibition 8.1 pKd 7.0 Kd
mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 Hs Inhibitor Inhibition 8.1 pKd 8.2 Kd
mitogen-activated protein kinase kinase 5 MEK5 Hs Inhibitor Inhibition 8.1 pKd 8.2 Kd
EPH receptor B2 EPHB2 Hs Inhibitor Inhibition 8.1 pKd 8.4 Kd
EPH receptor A8 EPHA8 Hs Inhibitor Inhibition 8.1 pKd 9.0 Kd
EPH receptor B4 EPHB4 Hs Inhibitor Inhibition 8.0 pKd 9.2 Kd
mitogen-activated protein kinase kinase 2 MEK2 Hs Inhibitor Inhibition 8.0 pKd 9.9 Kd
FYN proto-oncogene, Src family tyrosine kinase FYN Hs Inhibitor Inhibition 8.0 pKd 11.0 Kd
mitogen-activated protein kinase kinase kinase kinase 1 HPK1 Hs Inhibitor Inhibition 7.8 pKd 15.0 Kd
mitogen-activated protein kinase kinase kinase 19 YSK4 Hs Inhibitor Inhibition 7.8 pKd 16.0 Kd
epidermal growth factor receptor EGFR(E746-A750del) Hs Inhibitor Inhibition 7.7 pKd 18.0 Kd
EPH receptor A2 EPHA2 Hs Inhibitor Inhibition 7.7 pKd 18.0 Kd
EPH receptor A4 EPHA4 Hs Inhibitor Inhibition 7.7 pKd 18.0 Kd
mitogen-activated protein kinase kinase 1 MEK1 Hs Inhibitor Inhibition 7.7 pKd 19.0 Kd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-nonphosphorylated Hs Inhibitor Inhibition 7.7 pKd 21.0 Kd
epidermal growth factor receptor EGFR(L858R) Hs Inhibitor Inhibition 7.6 pKd 23.0 Kd
epidermal growth factor receptor EGFR(G719S) Hs Inhibitor Inhibition 7.6 pKd 26.0 Kd
erb-b2 receptor tyrosine kinase 4 ERBB4 Hs Inhibitor Inhibition 7.6 pKd 26.0 Kd
EPH receptor A5 EPHA5 Hs Inhibitor Inhibition 7.6 pKd 27.0 Kd
epidermal growth factor receptor EGFR(L747-E749del, A750P) Hs Inhibitor Inhibition 7.5 pKd 29.0 Kd
salt inducible kinase 2 SIK2 Hs Inhibitor Inhibition 7.5 pKd 29.0 Kd
tyrosine kinase non receptor 2 TNK2 Hs Inhibitor Inhibition 7.5 pKd 29.0 Kd
epidermal growth factor receptor EGFR(L747-T751del,Sins) Hs Inhibitor Inhibition 7.5 pKd 30.0 Kd
mitogen-activated protein kinase kinase kinase 2 MAP3K2 Hs Inhibitor Inhibition 7.5 pKd 30.0 Kd
salt inducible kinase 1 SIK Hs Inhibitor Inhibition 7.5 pKd 30.0 Kd
TRAF2 and NCK interacting kinase TNIK Hs Inhibitor Inhibition 7.5 pKd 31.0 Kd
C-terminal Src kinase CSK Hs Inhibitor Inhibition 7.5 pKd 32.0 Kd
EPH receptor B1 EPHB1 Hs Inhibitor Inhibition 7.5 pKd 33.0 Kd
epidermal growth factor receptor EGFR Hs Inhibitor Inhibition 7.5 pKd 35.0 Kd
serine/threonine-protein kinase MST4 MST4 Hs Inhibitor Inhibition 7.4 pKd 37.0 Kd
serine/threonine kinase 33 STK33 Hs Inhibitor Inhibition 7.4 pKd 37.0 Kd
epidermal growth factor receptor EGFR(L747-S752del, P753S) Hs Inhibitor Inhibition 7.4 pKd 38.0 Kd
AXL receptor tyrosine kinase AXL Hs Inhibitor Inhibition 7.3 pKd 52.0 Kd
inhibitor of nuclear factor kappa B kinase subunit epsilon IKK-epsilon Hs Inhibitor Inhibition 7.3 pKd 53.0 Kd
mitogen-activated protein kinase kinase kinase 3 MAP3K3 Hs Inhibitor Inhibition 7.3 pKd 54.0 Kd
TYRO3 protein tyrosine kinase TYRO3 Hs Inhibitor Inhibition 7.2 pKd 61.0 Kd
SIK family kinase 3 QSK Hs Inhibitor Inhibition 7.2 pKd 64.0 Kd
epidermal growth factor receptor EGFR(L861Q) Hs Inhibitor Inhibition 7.2 pKd 71.0 Kd
TXK tyrosine kinase TXK Hs Inhibitor Inhibition 7.1 pKd 72.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(D816V) Hs Inhibitor Inhibition 7.1 pKd 73.0 Kd
ZAK sterile alpha motif and leucine zipper containing kinase AZK ZAK Hs Inhibitor Inhibition 7.1 pKd 80.0 Kd
DM1 protein kinase DMPK Hs Inhibitor Inhibition 7.0 pKd 91.0 Kd
WEE2 oocyte meiosis inhibiting kinase WEE2 Hs Inhibitor Inhibition 7.0 pKd 94.0 Kd
epidermal growth factor receptor EGFR(G719C) Hs Inhibitor Inhibition 7.0 pKd 98.0 Kd
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites SRMS Hs Inhibitor Inhibition 7.0 pKd 100.0 Kd
mitogen-activated protein kinase kinase kinase 7 TAK1 Hs Inhibitor Inhibition 7.0 pKd 100.0 Kd
casein kinase 1 epsilon CSNK1E Hs Inhibitor Inhibition 7.0 pKd 110.0 Kd
epidermal growth factor receptor EGFR(S752-I759del) Hs Inhibitor Inhibition 7.0 pKd 110.0 Kd
mitogen-activated protein kinase kinase kinase 4 MAP3K4 Hs Inhibitor Inhibition 7.0 pKd 110.0 Kd
MER proto-oncogene, tyrosine kinase MERTK Hs Inhibitor Inhibition 7.0 pKd 110.0 Kd
checkpoint kinase 2 CHEK2 Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
discoidin domain receptor tyrosine kinase 1 DDR1 Hs Inhibitor Inhibition 6.9 pKd 120.0 Kd
homeodomain interacting protein kinase 4 HIPK4 Hs Inhibitor Inhibition 6.9 pKd 130.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,V654A) Hs Inhibitor Inhibition 6.9 pKd 130.0 Kd
discoidin domain receptor tyrosine kinase 2 DDR2 Hs Inhibitor Inhibition 6.8 pKd 140.0 Kd
TNNI3 interacting kinase TNNI3K Hs Inhibitor Inhibition 6.8 pKd 170.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(D816H) Hs Inhibitor Inhibition 6.7 pKd 180.0 Kd
serine/threonine kinase 4 MST1 Hs Inhibitor Inhibition 6.7 pKd 190.0 Kd
BMX non-receptor tyrosine kinase BMX Hs Inhibitor Inhibition 6.7 pKd 200.0 Kd
platelet derived growth factor receptor beta PDGFRB Hs Inhibitor Inhibition 6.7 pKd 200.0 Kd
EPH receptor B3 EPHB3 Hs Inhibitor Inhibition 6.7 pKd 210.0 Kd
NUAK family, SNF1-like kinase, 2 SNARK Hs Inhibitor Inhibition 6.7 pKd 220.0 Kd
casein kinase 1 delta CSNK1D Hs Inhibitor Inhibition 6.6 pKd 240.0 Kd
TANK binding kinase 1 TBK1 Hs Inhibitor Inhibition 6.6 pKd 250.0 Kd
eukaryotic translation initiation factor 2 alpha kinase 4 GCN2(Kin.Dom.2,S808G) Hs Inhibitor Inhibition 6.6 pKd 270.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(A829P) Hs Inhibitor Inhibition 6.6 pKd 270.0 Kd
casein kinase 1 alpha 1 CSNK1A1 Hs Inhibitor Inhibition 6.6 pKd 280.0 Kd
spleen associated tyrosine kinase SYK Hs Inhibitor Inhibition 6.5 pKd 290.0 Kd
CDC like kinase 3 CLK3 Hs Inhibitor Inhibition 6.5 pKd 300.0 Kd
FES proto-oncogene, tyrosine kinase FES Hs Inhibitor Inhibition 6.5 pKd 330.0 Kd
epidermal growth factor receptor EGFR(T790M) Hs Inhibitor Inhibition 6.5 pKd 340.0 Kd
phosphorylase kinase catalytic subunit gamma 1 PHKG1 Hs Inhibitor Inhibition 6.5 pKd 340.0 Kd
TAO kinase 3 TAOK3 Hs Inhibitor Inhibition 6.5 pKd 340.0 Kd
BMP2 inducible kinase BIKE Hs Inhibitor Inhibition 6.5 pKd 350.0 Kd
Microtubule associated serine/threonine kinase 1 MAST1 Hs Inhibitor Inhibition 6.5 pKd 350.0 Kd
protein kinase, membrane associated tyrosine/threonine 1 PKMYT1 Hs Inhibitor Inhibition 6.5 pKd 350.0 Kd
FER tyrosine kinase FER Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
interleukin 1 receptor associated kinase 4 IRAK4 Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
Rho associated coiled-coil containing protein kinase 2 ROCK2 Hs Inhibitor Inhibition 6.4 pKd 360.0 Kd
serine/threonine kinase 3 MST2 Hs Inhibitor Inhibition 6.4 pKd 370.0 Kd
colony stimulating factor 1 receptor CSF1R Hs Inhibitor Inhibition 6.4 pKd 380.0 Kd
serine/threonine kinase 24 MST3 Hs Inhibitor Inhibition 6.4 pKd 380.0 Kd
dual serine/threonine and tyrosine protein kinase RIPK5 Hs Inhibitor Inhibition 6.4 pKd 380.0 Kd
epidermal growth factor receptor EGFR(L858R,T790M) Hs Inhibitor Inhibition 6.4 pKd 390.0 Kd
protein tyrosine kinase 2 beta PYK2 Hs Inhibitor Inhibition 6.4 pKd 390.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT Hs Inhibitor Inhibition 6.4 pKd 420.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D) Hs Inhibitor Inhibition 6.4 pKd 430.0 Kd
unc-51 like autophagy activating kinase 2 ULK2 Hs Inhibitor Inhibition 6.3 pKd 450.0 Kd
unc-51 like kinase 3 ULK3 Hs Inhibitor Inhibition 6.3 pKd 460.0 Kd
mitogen-activated protein kinase kinase kinase 13 LZK Hs Inhibitor Inhibition 6.3 pKd 480.0 Kd
myosin light chain kinase MYLK Hs Inhibitor Inhibition 6.3 pKd 490.0 Kd
leucine rich repeat kinase 2 LRRK2 Hs Inhibitor Inhibition 6.3 pKd 500.0 Kd
WEE1 G2 checkpoint kinase WEE1 Hs Inhibitor Inhibition 6.3 pKd 510.0 Kd
homeodomain interacting protein kinase 1 HIPK1 Hs Inhibitor Inhibition 6.3 pKd 520.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(L576P) Hs Inhibitor Inhibition 6.3 pKd 520.0 Kd
calcium/calmodulin dependent protein kinase ID CAMK1D Hs Inhibitor Inhibition 6.3 pKd 550.0 Kd
protein tyrosine kinase 2 FAK Hs Inhibitor Inhibition 6.2 pKd 570.0 Kd
serine/threonine kinase 36 STK36 Hs Inhibitor Inhibition 6.2 pKd 570.0 Kd
tousled like kinase 1 TLK1 Hs Inhibitor Inhibition 6.2 pKd 570.0 Kd
bone morphogenetic protein receptor type 2 BMPR2 Hs Inhibitor Inhibition 6.2 pKd 580.0 Kd
CDC like kinase 1 CLK1 Hs Inhibitor Inhibition 6.2 pKd 600.0 Kd
interleukin 1 receptor associated kinase 1 IRAK1 Hs Inhibitor Inhibition 6.2 pKd 600.0 Kd
eukaryotic translation initiation factor 2 alpha kinase 1 EIF2AK1 Hs Inhibitor Inhibition 6.2 pKd 630.0 Kd
NIMA related kinase 11 NEK11 Hs Inhibitor Inhibition 6.2 pKd 650.0 Kd
ribosomal protein S6 kinase B1 S6K1 Hs Inhibitor Inhibition 6.2 pKd 660.0 Kd
mitogen-activated protein kinase kinase kinase 12 DLK Hs Inhibitor Inhibition 6.2 pKd 670.0 Kd
ALK receptor tyrosine kinase ALK Hs Inhibitor Inhibition 6.2 pKd 690.0 Kd
VRK serine/threonine kinase 2 VRK2 Hs Inhibitor Inhibition 6.2 pKd 710.0 Kd
calcium/calmodulin dependent protein kinase kinase 2 CAMKK2 Hs Inhibitor Inhibition 6.1 pKd 780.0 Kd
calcium/calmodulin dependent serine protein kinase CASK Hs Inhibitor Inhibition 6.1 pKd 830.0 Kd
leucine rich repeat kinase 2 LRRK2(G2019S) Hs Inhibitor Inhibition 6.1 pKd 830.0 Kd
Rho associated coiled-coil containing protein kinase 1 ROCK1 Hs Inhibitor Inhibition 6.1 pKd 870.0 Kd
serine/threonine kinase 25 YSK1 Hs Inhibitor Inhibition 6.1 pKd 900.0 Kd
protein kinase C theta PRKCQ Hs Inhibitor Inhibition 6.0 pKd 910.0 Kd
polo like kinase 2 PLK2 Hs Inhibitor Inhibition 6.0 pKd 960.0 Kd
colony stimulating factor 1 receptor CSF1R-autoinhibited Hs Inhibitor Inhibition 6.0 pKd 1000.0 Kd
fms related receptor tyrosine kinase 3 FLT3(D835H) Hs Inhibitor Inhibition 6.0 pKd 1000.0 Kd
EPH receptor A6 EPHA6 Hs Inhibitor Inhibition 6.0 pKd 1100.0 Kd
fms related receptor tyrosine kinase 3 FLT3(D835Y) Hs Inhibitor Inhibition 6.0 pKd 1100.0 Kd
Janus kinase 2 JAK2(JH1domain-catalytic) Hs Inhibitor Inhibition 6.0 pKd 1100.0 Kd
cyclin dependent kinase 7 CDK7 Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
Janus kinase 3 JAK3(JH1domain-catalytic) Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
ribosomal protein S6 kinase A3 RSK2(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
neurotrophic receptor tyrosine kinase 2 TRKB Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
unc-51 like autophagy activating kinase 1 ULK1 Hs Inhibitor Inhibition 5.9 pKd 1200.0 Kd
mitogen-activated protein kinase kinase 6 MEK6 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
phosphorylase kinase catalytic subunit gamma 2 PHKG2 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
TAO kinase 1 TAOK1 Hs Inhibitor Inhibition 5.9 pKd 1300.0 Kd
cyclin dependent kinase 14 PFTK1 Hs Inhibitor Inhibition 5.8 pKd 1400.0 Kd
serine/threonine-protein kinase NIM1 NIM1 Hs Inhibitor Inhibition 5.8 pKd 1500.0 Kd
NIMA related kinase 2 NEK2 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
cyclin dependent kinase 15 PFTAIRE2 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
protein kinase C delta PRKCD Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
RIO kinase 3 RIOK3 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
zeta chain of T cell receptor associated protein kinase 70 ZAP70 Hs Inhibitor Inhibition 5.8 pKd 1600.0 Kd
CDC like kinase 2 CLK2 Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
G protein-coupled receptor kinase 7 GRK7 Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
IL2 inducible T cell kinase ITK Hs Inhibitor Inhibition 5.8 pKd 1700.0 Kd
polo like kinase 1 PLK1 Hs Inhibitor Inhibition 5.7 pKd 1800.0 Kd
serine/threonine kinase 32A YANK1 Hs Inhibitor Inhibition 5.7 pKd 1800.0 Kd
homeodomain interacting protein kinase 2 HIPK2 Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
p21 (RAC1) activated kinase 2 PAK2 Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
TAO kinase 2 TAOK2 Hs Inhibitor Inhibition 5.7 pKd 1900.0 Kd
ankyrin repeat and kinase domain containing 1 ANKK1 Hs Inhibitor Inhibition 5.7 pKd 2100.0 Kd
tousled like kinase 2 TLK2 Hs Inhibitor Inhibition 5.7 pKd 2100.0 Kd
fms related receptor tyrosine kinase 3 FLT3 Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
fms related receptor tyrosine kinase 3 FLT3(K663Q) Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
MET proto-oncogene, receptor tyrosine kinase MET Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
nemo like kinase NLK Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
RIO kinase 1 RIOK1 Hs Inhibitor Inhibition 5.7 pKd 2200.0 Kd
AP2 associated kinase 1 AAK1 Hs Inhibitor Inhibition 5.6 pKd 2300.0 Kd
EPH receptor A1 EPHA1 Hs Inhibitor Inhibition 5.6 pKd 2300.0 Kd
mitogen-activated protein kinase 7 ERK5 Hs Inhibitor Inhibition 5.6 pKd 2300.0 Kd
myosin IIIB MYO3B Hs Inhibitor Inhibition 5.6 pKd 2300.0 Kd
p21 (RAC1) activated kinase 1 PAK1 Hs Inhibitor Inhibition 5.6 pKd 2300.0 Kd
citron rho-interacting serine/threonine kinase CIT Hs Inhibitor Inhibition 5.6 pKd 2400.0 Kd
cyclin dependent kinase 16 PCTK1 Hs Inhibitor Inhibition 5.6 pKd 2400.0 Kd
protein kinase C epsilon PRKCE Hs Inhibitor Inhibition 5.6 pKd 2400.0 Kd
erb-b2 receptor tyrosine kinase 2 ERBB2 Hs Inhibitor Inhibition 5.6 pKd 2500.0 Kd
casein kinase 1 alpha 1 like CSNK1A1L Hs Inhibitor Inhibition 5.6 pKd 2600.0 Kd
mitogen-activated protein kinase kinase 3 MEK3 Hs Inhibitor Inhibition 5.6 pKd 2600.0 Kd
mitogen-activated protein kinase kinase 4 MEK4 Hs Inhibitor Inhibition 5.6 pKd 2600.0 Kd
mitogen-activated protein kinase kinase kinase 9 MLK1 Hs Inhibitor Inhibition 5.6 pKd 2700.0 Kd
mitogen-activated protein kinase kinase kinase 11 MLK3 Hs Inhibitor Inhibition 5.6 pKd 2700.0 Kd
ribosomal protein S6 kinase A6 RSK4(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 5.6 pKd 2700.0 Kd
fms related receptor tyrosine kinase 3 FLT3(ITD) Hs Inhibitor Inhibition 5.5 pKd 2900.0 Kd
protein kinase N1 PKN1 Hs Inhibitor Inhibition 5.5 pKd 2900.0 Kd
tyrosine kinase with immunoglobulin like and EGF like domains 1 TIE1 Hs Inhibitor Inhibition 5.5 pKd 2900.0 Kd
activin A receptor type 1 ACVR1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
activin A receptor type 1B ACVR1B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
activin A receptor type 2A ACVR2A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
activin A receptor type 2B ACVR2B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
activin A receptor type IL ACVRL1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
coenzyme Q8A ADCK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
coenzyme Q8B ADCK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
AKT serine/threonine kinase 1 AKT1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
AKT serine/threonine kinase 2 AKT2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
AKT serine/threonine kinase 3 AKT3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase AMP-activated catalytic subunit alpha 2 AMPK-alpha2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 5 ASK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 6 ASK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
aurora kinase A AURKA Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
aurora kinase B AURKB Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
aurora kinase C AURKC Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
bone morphogenetic protein receptor type IA BMPR1A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
bone morphogenetic protein receptor type IB BMPR1B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
B-Raf proto-oncogene, serine/threonine kinase BRAF Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
B-Raf proto-oncogene, serine/threonine kinase BRAF(V600E) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein tyrosine kinase 6 BRK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
BR serine/threonine kinase 1 BRSK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
BR serine/threonine kinase 2 BRSK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
calcium/calmodulin dependent protein kinase I CAMK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
calcium/calmodulin dependent protein kinase IG CAMK1G Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
calcium/calmodulin-dependent protein kinase II beta subunit CAMK2B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
calcium/calmodulin-dependent protein kinase II delta subunit CAMK2D Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
calcium/calmodulin dependent protein kinase IV CAMK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
calcium/calmodulin dependent protein kinase kinase 1 CAMKK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 11B CDC2L1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 11A CDC2L2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 13 CDC2L5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 19 CDK11 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 2 CDK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 3 CDK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 4 CDK4-cyclinD1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 4 CDK4-cyclinD3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 5 CDK5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 8 CDK8 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 9 CDK9 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase like 1 CDKL1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase like 2 CDKL2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin-dependent kinase like 3 CDKL3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin-dependent kinase like 4 CDKL5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
checkpoint kinase 1 CHEK1 Hs Inhibitor Inhibition 5.5 pKd 3000.0 Kd
casein kinase 1 gamma 1 CSNK1G1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 gamma 2 CSNK1G2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 1 gamma 3 CSNK1G3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 2, alpha 1 polypeptide subunit CSNK2A1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
casein kinase 2, alpha prime polypeptide subunit CSNK2A2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
death associated protein kinase 1 DAPK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
death associated protein kinase 2 DAPK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
death associated protein kinase 3 DAPK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
doublecortin like kinase 1 DCAMKL1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
doublecortin like kinase 2 DCAMKL2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
CDC42 binding protein kinase gamma DMPK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 17a DRAK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 17b DRAK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
dual specificity tyrosine phosphorylation regulated kinase 1A DYRK1A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
dual specificity tyrosine phosphorylation regulated kinase 1B DYRK1B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
dual specificity tyrosine phosphorylation regulated kinase 2 DYRK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
EPH receptor A7 EPHA7 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
EPH receptor B6 EPHB6 Hs Inhibitor Inhibition 5.5 pKd 3000.0 Kd
mitogen-activated protein kinase 3 ERK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 1 ERK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 6 ERK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 4 ERK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 15 ERK8 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
endoplasmic reticulum to nucleus signaling 1 ERN1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fibroblast growth factor receptor 1 FGFR1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fibroblast growth factor receptor 2 FGFR2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fibroblast growth factor receptor 3 FGFR3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fibroblast growth factor receptor 3 FGFR3(G697C) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fibroblast growth factor receptor 4 FGFR4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fms related receptor tyrosine kinase 1 FLT1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fms related receptor tyrosine kinase 3 FLT3(R834Q) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
fms related receptor tyrosine kinase 4 FLT4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
G protein-coupled receptor kinase 1 GRK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
glycogen synthase kinase 3 alpha GSK3A Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
glycogen synthase kinase 3 beta GSK3B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ciliogenesis associated kinase 1 ICK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Insulin-like growth factor I receptor IGF1R Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
component of inhibitor of nuclear factor kappa B kinase complex IKK-alpha Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
inhibitor of nuclear factor kappa B kinase subunit beta IKK-beta Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Insulin receptor INSR Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Insulin receptor-related receptor INSRR Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
interleukin 1 receptor associated kinase 3 IRAK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Janus kinase 1 JAK1(JH1domain-catalytic) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Janus kinase 1 JAK1(JH2domain-pseudokinase) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 8 JNK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 9 JNK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 10 JNK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,T670I) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
large tumor suppressor kinase 1 LATS1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
large tumor suppressor kinase 2 LATS2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
LIM domain kinase 1 LIMK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
LIM domain kinase 2 LIMK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 11 LKB1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
leukocyte receptor tyrosine kinase LTK Hs Inhibitor Inhibition 5.5 pKd 3000.0 Kd
male germ cell associated kinase MAK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 15 MAP3K15 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MAPK activated protein kinase 2 MAPKAPK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MAPK activated protein kinase 5 MAPKAPK5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
microtubule affinity regulating kinase 1 MARK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
microtubule affinity regulating kinase 2 MARK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
microtubule affinity regulating kinase 3 MARK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
microtubule affinity regulating kinase 4 MARK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
maternal embryonic leucine zipper kinase MELK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MAPK interacting serine/threonine kinase 1 MKNK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MAPK interacting serine/threonine kinase 2 MKNK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
myosin light chain kinase 3 MLCK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase kinase kinase 10 MLK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
CDC42 binding protein kinase alpha MRCKA Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
CDC42 binding protein kinase beta MRCKB Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mechanistic target of rapamycin kinase MTOR Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
muscle associated receptor tyrosine kinase MUSK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
myosin light chain kinase 2 MYLK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
myosin light chain kinase family member 4 MYLK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Serine/threonine kinase 38 NDR1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Serine/threonine kinase 38 like NDR2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
NIMA related kinase 1 NEK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
NIMA related kinase 3 NEK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
NIMA related kinase 4 NEK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
NIMA related kinase 5 NEK5 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
NIMA related kinase 6 NEK6 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
NIMA related kinase 7 NEK7 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
NIMA related kinase 8 NEK9 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
oxidative stress responsive kinase 1 OSR1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 14 p38-alpha Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 11 p38-beta Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 13 p38-delta Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
mitogen-activated protein kinase 12 p38-gamma Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
p21 (RAC1) activated kinase 4 PAK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
p21 (RAC1) activated kinase 6 PAK6 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
p21 (RAC1) activated kinase 5 PAK7 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 17 PCTK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
cyclin dependent kinase 18 PCTK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
3-phosphoinositide dependent protein kinase 1 PDPK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C2G Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(C420R) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(E542K) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(E545A) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(E545K) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(H1047L) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(H1047Y) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(I800L) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(M1043I) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CA(Q546K) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CB Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CD Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3CG Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol 4-kinase alpha PIK4CB Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Pim-1 proto-oncogene, serine/threonine kinase PIM1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Pim-2 proto-oncogene, serine/threonine kinase PIM2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Pim-3 proto-oncogene, serine/threonine kinase PIM3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma PIP5K1C Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-5-phosphate 4-kinase type 2 beta PIP5K2B Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma PIP5K2C Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase, cAMP-dependent, catalytic, alpha subunit PKAC-alpha Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase, cAMP-dependent, catalytic, beta subunit PKAC-beta Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
polo like kinase 3 PLK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
polo like kinase 4 PLK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase C eta PRKCH Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase C iota PRKCI Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase D1 PRKD1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase D2 PRKD2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Protein kinase G (PKG) 1 PRKG1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Protein kinase G (PKG) 2 PRKG2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
eukaryotic translation initiation factor 2 alpha kinase 2 PRKR Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
protein kinase X-linked PRKX Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
pre-mRNA processing factor kinase PRP4K PRP4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
Raf-1 proto-oncogene, serine/threonine kinase RAF1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ret proto-oncogene RET(V804L) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
RIO kinase 2 RIOK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
receptor interacting serine/threonine kinase 1 RIPK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
receptor interacting serine/threonine kinase 4 RIPK4 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
c-ros oncogene 1, receptor tyrosine kinase ROS1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A4 RPS6KA4(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A4 RPS6KA4(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A5 RPS6KA5(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A5 RPS6KA5(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A1 RSK1(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A1 RSK1(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A2 RSK3(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
ribosomal protein S6 kinase A6 RSK4(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
SH3 domain binding kinase 1 SBK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
sugen kinase 110 SgK110 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serum/glucocorticoid regulated kinase family member 3 SGK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
SNF related kinase SNRK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
SRSF protein kinase 1 SRPK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
SRSF protein kinase 2 SRPK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 16 STK16 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
testis associated actin remodelling kinase 1 TESK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
transforming growth factor beta receptor 1 TGFBR1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
transforming growth factor beta receptor 2 TGFBR2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
tyrosine kinase non receptor 1 TNK1 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
TRPM6 TRPM6 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
TTK protein kinase TTK Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
kinase insert domain receptor VEGFR2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 32B YANK2 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
serine/threonine kinase 32C YANK3 Hs Inhibitor Inhibition <5.5 pKd >3000.0 Kd
MET proto-oncogene, receptor tyrosine kinase MET(Y1235D) Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
neurotrophic receptor tyrosine kinase 1 TRKA Hs Inhibitor Inhibition 5.5 pKd 3100.0 Kd
CDC like kinase 4 CLK4 Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
homeodomain interacting protein kinase 3 HIPK3 Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
protein kinase N2 PKN2 Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
ribosomal protein S6 kinase A2 RSK3(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
tec protein tyrosine kinase TEC Hs Inhibitor Inhibition 5.5 pKd 3200.0 Kd
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha PIP5K1A Hs Inhibitor Inhibition 5.5 pKd 3300.0 Kd
fms related receptor tyrosine kinase 3 FLT3(N841I) Hs Inhibitor Inhibition 5.5 pKd 3400.0 Kd
neurotrophic receptor tyrosine kinase 3 TRKC Hs Inhibitor Inhibition 5.5 pKd 3400.0 Kd
calcium/calmodulin-dependent protein kinase II gamma subunit CAMK2G Hs Inhibitor Inhibition 5.4 pKd 3600.0 Kd
receptor interacting serine/threonine kinase 2 RIPK2 Hs Inhibitor Inhibition 5.4 pKd 3700.0 Kd
serine/threonine kinase 39 STK39 Hs Inhibitor Inhibition 5.4 pKd 3700.0 Kd
ret proto-oncogene RET(M918T) Hs Inhibitor Inhibition 5.4 pKd 3800.0 Kd
protein kinase AMP-activated catalytic subunit alpha 1 AMPK-alpha1 Hs Inhibitor Inhibition 5.4 pKd 3900.0 Kd
SRSF protein kinase 3 SRPK3 Hs Inhibitor Inhibition 5.4 pKd 3900.0 Kd
TEK receptor tyrosine kinase TIE2 Hs Inhibitor Inhibition 5.4 pKd 3900.0 Kd
ret proto-oncogene RET(V804M) Hs Inhibitor Inhibition 5.4 pKd 4200.0 Kd
mitogen-activated protein kinase kinase kinase 1 MAP3K1 Hs Inhibitor Inhibition 5.4 pKd 4400.0 Kd
calcium/calmodulin-dependent protein kinase II alpha subunit CAMK2A Hs Inhibitor Inhibition 5.3 pKd 4500.0 Kd
tyrosine kinase 2 TYK2(JH2domain-pseudokinase) Hs Inhibitor Inhibition 5.3 pKd 4500.0 Kd
protein kinase D3 PRKD3 Hs Inhibitor Inhibition 5.3 pKd 4600.0 Kd
testis specific serine kinase 1B TSSK1B Hs Inhibitor Inhibition 5.3 pKd 4600.0 Kd
ret proto-oncogene RET Hs Inhibitor Inhibition 5.3 pKd 4800.0 Kd
G protein-coupled receptor kinase 4 GRK4 Hs Inhibitor Inhibition 5.3 pKd 4900.0 Kd
hormonally up-regulated Neu-associated kinase HUNK Hs Inhibitor Inhibition 5.3 pKd 5000.0 Kd
platelet derived growth factor receptor alpha PDGFRA Hs Inhibitor Inhibition 5.3 pKd 5100.0 Kd
mitogen-activated protein kinase kinase 7 MKK7 Hs Inhibitor Inhibition 5.3 pKd 5300.0 Kd
doublecortin like kinase 3 DCAMKL3 Hs Inhibitor Inhibition 5.3 pKd 5400.0 Kd
p21 (RAC1) activated kinase 3 PAK3 Hs Inhibitor Inhibition 5.2 pKd 5700.0 Kd
megakaryocyte-associated tyrosine kinase CTK Hs Inhibitor Inhibition 5.2 pKd 5800.0 Kd
NUAK family kinase 1 ARK5 Hs Inhibitor Inhibition 5.2 pKd 5900.0 Kd
myosin IIIA MYO3A Hs Inhibitor Inhibition 5.2 pKd 6200.0 Kd
macrophage stimulating 1 receptor MST1R Hs Inhibitor Inhibition 5.2 pKd 6300.0 Kd
tyrosine kinase 2 TYK2(JH1domain-catalytic) Hs Inhibitor Inhibition 5.2 pKd 6500.0 Kd
MET proto-oncogene, receptor tyrosine kinase MET(M1250T) Hs Inhibitor Inhibition 5.2 pKd 6800.0 Kd
KIT proto-oncogene, receptor tyrosine kinase KIT-autoinhibited Hs Inhibitor Inhibition 5.1 pKd 9000.0 Kd

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]