Top ▲

Taste 2 receptors C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Taste 2 receptors or Bitter taste receptors (TAS2Rs) are G protein-coupled receptors expressed in oral sensory cells and a variety of non-gustatory tissues. The ~25 human TAS2Rs share low amino acid sequence identities with other GPCR families and are classified as broadly tuned "generalist" receptors with numerous, chemically diverse bitter agonists, as narrowly tuned "specialist" receptors with very few activators, as intermediately tuned receptors with an average number of agonists, or receptors specialized to interact with chemically defined activators [32]. The number of functional bitter taste receptor genes varies among species and orthologues might not be functionally conserved. Due to their expression in various tissues, the signal transduction of TAS2Rs is complex. Some TAS2Rs interact with drugs such as analgesic, anti-inflammatory, and antibacterial compounds. The specialist database BitterDB contains additional information on bitter compounds and receptors [13].

Receptors

678
Click here for help

TAS2R1 C Show summary »

TAS2R3 C Show summary »

TAS2R4 C Show summary »

TAS2R5 C Show summary »

TAS2R7 C Show summary »

TAS2R8 C Show summary »

TAS2R9 C Show summary »

TAS2R10 C Show summary »

TAS2R13 C Show summary »

TAS2R14 C Show summary »

TAS2R16 C Show summary »

TAS2R19 C Show summary »

TAS2R20 C Show summary »

TAS2R30 C Show summary »

TAS2R31 C Show summary »

TAS2R38 C Show summary »

TAS2R39 C Show summary »

TAS2R40 C Show summary »

TAS2R41 C Show summary »

TAS2R42 C Show summary »

TAS2R43 C Show summary »


Target Id 678
Nomenclature TAS2R43
Previous and unofficial names T2R52 | taste receptor, type 2, member 43
Genes TAS2R43 (Hs)
Ensembl ID ENSG00000255374 (Hs)
UniProtKB AC P59537 (Hs)
BitterDB 43 (Hs)
Principal transduction -
Agonists
aristolochic acid [26]
lactucopicrin [27]
aloin [36]
Cyclolinopeptide 1-Mso,3-Met-CL6 [28]
bengalensol [29]
grosheimin [41]
amarogentin [32]
saccharin [26]
acesulfame [26]
Antagonists
GIV3727 pIC50 4.9 [43]
3-methylhexanal pIC50 4.1 [46]
citronellal pIC50 4.1 [46]
cyclamate pIC50 2.3 [1]

TAS2R45 C Show summary »

TAS2R46 C Show summary »

TAS2R50 C Show summary »

TAS2R60 C Show summary »

Further reading

Click here for help

Show »

References

Click here for help

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 180 Suppl 2:S23-S144.