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SLC16 family of monocarboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of the SLC16 family may be divided into subfamilies on the basis of substrate selectivities, particularly lactate (e.g. L-lactic acid), pyruvic acid and ketone bodies, as well as aromatic amino acids. Topology modelling suggests 12 TM domains, with intracellular termini and an extended loop at TM 6/7.

The proton-coupled monocarboxylate transporters (monocarboxylate transporters 1, 4, 2 and 3) allow transport of the products of cellular metabolism, principally lactate (e.g. L-lactic acid) and pyruvic acid.

Transporters

1001
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MCT1 (Monocarboxylate transporter 1 / SLC16A1) C Show summary »

MCT2 (Monocarboxylate transporter 2 / SLC16A7) C Show summary »

MCT3 (Monocarboxylate transporter 3 / SLC16A8) C Show summary »

MCT4 (Monocarboxylate transporter 4 / SLC16A3) C Show summary »

MCT5 (Monocarboxylate transporter 5 / SLC16A4) Show summary »

MCT6 (Monocarboxylate transporter 6 / SLC16A5) C Show summary »

MCT7 (Monocarboxylate transporter 7 / SLC16A6) Show summary »

MCT8 (Monocarboxylate transporter 8 / SLC16A2) C Show summary »

MCT9 (Monocarboxylate transporter 9 / SLC16A9) Show summary »

TAT1 (Monocarboxylate transporter 10 / SLC16A10) C Show summary »

MCT11 (Monocarboxylate transporter 11 / SLC16A11) Show summary »

MCT12 (Monocarboxylate transporter 12 / SLC16A12) Show summary »

MCT13 (Monocarboxylate transporter 13 / SLC16A13) Show summary »

MCT14 (Monocarboxylate transporter 14 / SLC16A14) Show summary »


Target Id 1001
Nomenclature Monocarboxylate transporter 14
Systematic nomenclature SLC16A14
Common abbreviation MCT14
Previous and unofficial names solute carrier family 16 (monocarboxylic acid transporters), member 14 | solute carrier family 16, member 14 | solute carrier family 16 | solute carrier family 16 (monocarboxylic acid transporters)
Genes SLC16A14 (Hs), Slc16a14 (Mm), Slc16a14 (Rn)
Ensembl ID ENSG00000163053 (Hs), ENSMUSG00000026220 (Mm), ENSRNOG00000017072 (Rn)
UniProtKB AC Q7RTX9 (Hs), Q8K1C7 (Mm)
Bioparadigms SLC Tables SLC16A14 (Hs)
Stoichiometry Unknown

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How to cite this family page

Database page citation:

SLC16 family of monocarboxylate transporters. Accessed on 24/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=188.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.