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SLC16 family of monocarboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Members of the SLC16 family may be divided into subfamilies on the basis of substrate selectivities, particularly lactate (e.g. L-lactic acid), pyruvic acid and ketone bodies, as well as aromatic amino acids. Topology modelling suggests 12 TM domains, with intracellular termini and an extended loop at TM 6/7.

The proton-coupled monocarboxylate transporters (monocarboxylate transporters 1, 4, 2 and 3) allow transport of the products of cellular metabolism, principally lactate (e.g. L-lactic acid) and pyruvic acid.


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MCT1 (Monocarboxylate transporter 1 / SLC16A1) C Show summary »

Target Id 988
Nomenclature Monocarboxylate transporter 1
Systematic nomenclature SLC16A1
Common abbreviation MCT1
Previous and unofficial names MCT | Solute carrier 16 (monocarboxylic acid transporter) member 1 | solute carrier family 16 (monocarboxylate transporter), member 1 | solute carrier family 16 (monocarboxylic acid transporters)
Genes SLC16A1 (Hs), Slc16a1 (Mm), Slc16a1 (Rn)
Ensembl ID ENSG00000155380 (Hs), ENSMUSG00000032902 (Mm), ENSRNOG00000019996 (Rn)
UniProtKB AC P53985 (Hs), P53986 (Mm), P53987 (Rn)
Bioparadigms SLC Tables SLC16A1 (Hs)
Endogenous substrates
β-D-hydroxybutyric acid
L-lactic acid
pyruvic acid
γ-hydroxybutyrate [8]
AZD3965 pKi 8.5 [1]
compound 30 [PMID: 16455256] pKi 8.3 (Compound 30 is a channel blocker.) [4]
BAY-8002 pKi 8.3 [7]
BAY-8002 pIC50 9.0 [7]
Stoichiometry 1 H+ : 1 monocarboxylate- (out)

MCT2 (Monocarboxylate transporter 2 / SLC16A7) C Show summary »

MCT3 (Monocarboxylate transporter 3 / SLC16A8) C Show summary »

MCT4 (Monocarboxylate transporter 4 / SLC16A3) C Show summary »

MCT5 (Monocarboxylate transporter 5 / SLC16A4) Show summary »

MCT6 (Monocarboxylate transporter 6 / SLC16A5) C Show summary »

MCT7 (Monocarboxylate transporter 7 / SLC16A6) Show summary »

MCT8 (Monocarboxylate transporter 8 / SLC16A2) C Show summary »

MCT9 (Monocarboxylate transporter 9 / SLC16A9) Show summary »

TAT1 (Monocarboxylate transporter 10 / SLC16A10) C Show summary »

MCT11 (Monocarboxylate transporter 11 / SLC16A11) Show summary »

MCT12 (Monocarboxylate transporter 12 / SLC16A12) Show summary »

MCT13 (Monocarboxylate transporter 13 / SLC16A13) Show summary »

MCT14 (Monocarboxylate transporter 14 / SLC16A14) Show summary »


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Further reading

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How to cite this family page

Database page citation:

SLC16 family of monocarboxylate transporters. Accessed on 22/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.