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SLC16 family of monocarboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of the SLC16 family may be divided into subfamilies on the basis of substrate selectivities, particularly lactate (e.g. L-lactic acid), pyruvic acid and ketone bodies, as well as aromatic amino acids. Topology modelling suggests 12 TM domains, with intracellular termini and an extended loop at TM 6/7.

The proton-coupled monocarboxylate transporters (monocarboxylate transporters 1, 4, 2 and 3) allow transport of the products of cellular metabolism, principally lactate (e.g. L-lactic acid) and pyruvic acid.

Transporters

992
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MCT1 (Monocarboxylate transporter 1 / SLC16A1) C Show summary »

MCT2 (Monocarboxylate transporter 2 / SLC16A7) C Show summary »

MCT3 (Monocarboxylate transporter 3 / SLC16A8) C Show summary »

MCT4 (Monocarboxylate transporter 4 / SLC16A3) C Show summary »

MCT5 (Monocarboxylate transporter 5 / SLC16A4) Show summary »

MCT6 (Monocarboxylate transporter 6 / SLC16A5) C Show summary »

MCT7 (Monocarboxylate transporter 7 / SLC16A6) Show summary »

MCT8 (Monocarboxylate transporter 8 / SLC16A2) C Show summary »


Target Id 992
Nomenclature Monocarboxylate transporter 8
Systematic nomenclature SLC16A2
Common abbreviation MCT8
Previous and unofficial names Monocarboxylate transporter 7 | AHDS | MCT7 | MRX22 | XPCT | Allan-Herndon-Dudley syndrome | mental retardation, X-linked 22 | solute carrier family 16, member 2 (monocarboxylic acid transporter 8) | X-linked PEST-containing transporter | solute carrier family 16, member 2 (thyroid hormone transporter) | solute carrier family 16 (monocarboxylic acid transporters)
Genes SLC16A2 (Hs), Slc16a2 (Mm), Slc16a2 (Rn)
Ensembl ID ENSG00000147100 (Hs), ENSMUSG00000033965 (Mm), ENSRNOG00000002832 (Rn)
UniProtKB AC P36021 (Hs), O70324 (Mm), Q8K1P8 (Rn)
Bioparadigms SLC Tables SLC16A2 (Hs)
Endogenous substrates
triiodothyronine [3]
T4 [3]
Stoichiometry Unknown

MCT9 (Monocarboxylate transporter 9 / SLC16A9) Show summary »

TAT1 (Monocarboxylate transporter 10 / SLC16A10) C Show summary »

MCT11 (Monocarboxylate transporter 11 / SLC16A11) Show summary »

MCT12 (Monocarboxylate transporter 12 / SLC16A12) Show summary »

MCT13 (Monocarboxylate transporter 13 / SLC16A13) Show summary »

MCT14 (Monocarboxylate transporter 14 / SLC16A14) Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC16 family of monocarboxylate transporters. Accessed on 24/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=188.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.