Top ▲

SLC16 family of monocarboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Members of the SLC16 family may be divided into subfamilies on the basis of substrate selectivities, particularly lactate (e.g. L-lactic acid), pyruvic acid and ketone bodies, as well as aromatic amino acids. Topology modelling suggests 12 TM domains, with intracellular termini and an extended loop at TM 6/7.

The proton-coupled monocarboxylate transporters (monocarboxylate transporters 1, 4, 2 and 3) allow transport of the products of cellular metabolism, principally lactate (e.g. L-lactic acid) and pyruvic acid.

Transporters

993
Click here for help

MCT1 (Monocarboxylate transporter 1 / SLC16A1) C Show summary »

MCT2 (Monocarboxylate transporter 2 / SLC16A7) C Show summary »

MCT3 (Monocarboxylate transporter 3 / SLC16A8) C Show summary »

MCT4 (Monocarboxylate transporter 4 / SLC16A3) C Show summary »

MCT5 (Monocarboxylate transporter 5 / SLC16A4) Show summary »

MCT6 (Monocarboxylate transporter 6 / SLC16A5) C Show summary »

MCT7 (Monocarboxylate transporter 7 / SLC16A6) Show summary »

MCT8 (Monocarboxylate transporter 8 / SLC16A2) C Show summary »

MCT9 (Monocarboxylate transporter 9 / SLC16A9) Show summary »

TAT1 (Monocarboxylate transporter 10 / SLC16A10) C Show summary »


Target Id 993
Nomenclature Monocarboxylate transporter 10
Systematic nomenclature SLC16A10
Common abbreviation TAT1
Previous and unofficial names aromatic amino acid transporter 1 | MCT10 | T-type amino acid transporter 1 | solute carrier family 16 (monocarboxylic acid transporters), member 10 | solute carrier family 16 (aromatic amino acid transporter), member 10 | solute carrier family 16 (monocarboxylic acid transporters)
Genes SLC16A10 (Hs), Slc16a10 (Mm), Slc16a10 (Rn)
Ensembl ID ENSG00000112394 (Hs), ENSMUSG00000019838 (Mm), ENSRNOG00000000588 (Rn)
UniProtKB AC Q8TF71 (Hs), Q3U9N9 (Mm), Q91Y77 (Rn)
Bioparadigms SLC Tables SLC16A10 (Hs)
Endogenous substrates
L-tryptophan
L-phenylalanine
levodopa
L-tyrosine
Stoichiometry Unknown

MCT11 (Monocarboxylate transporter 11 / SLC16A11) Show summary »

MCT12 (Monocarboxylate transporter 12 / SLC16A12) Show summary »

MCT13 (Monocarboxylate transporter 13 / SLC16A13) Show summary »

MCT14 (Monocarboxylate transporter 14 / SLC16A14) Show summary »

Comments

Click here for help

Show »

Further reading

Click here for help

Show »

References

Click here for help

Show »

How to cite this family page

Database page citation:

SLC16 family of monocarboxylate transporters. Accessed on 23/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=188.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol. 176 Issue S1: S397-S493.