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SLC16 family of monocarboxylate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Members of the SLC16 family may be divided into subfamilies on the basis of substrate selectivities, particularly lactate (e.g. L-lactic acid), pyruvic acid and ketone bodies, as well as aromatic amino acids. Topology modelling suggests 12 TM domains, with intracellular termini and an extended loop at TM 6/7.

The proton-coupled monocarboxylate transporters (monocarboxylate transporters 1, 4, 2 and 3) allow transport of the products of cellular metabolism, principally lactate (e.g. L-lactic acid) and pyruvic acid.

Transporters

997
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MCT1 (Monocarboxylate transporter 1 / SLC16A1) C Show summary »

MCT2 (Monocarboxylate transporter 2 / SLC16A7) C Show summary »

MCT3 (Monocarboxylate transporter 3 / SLC16A8) C Show summary »

MCT4 (Monocarboxylate transporter 4 / SLC16A3) C Show summary »

MCT5 (Monocarboxylate transporter 5 / SLC16A4) Show summary »

MCT6 (Monocarboxylate transporter 6 / SLC16A5) C Show summary »

MCT7 (Monocarboxylate transporter 7 / SLC16A6) Show summary »

MCT8 (Monocarboxylate transporter 8 / SLC16A2) C Show summary »

MCT9 (Monocarboxylate transporter 9 / SLC16A9) Show summary »


Target Id 997
Nomenclature Monocarboxylate transporter 9
Systematic nomenclature SLC16A9
Common abbreviation MCT9
Previous and unofficial names solute carrier family 16 (monocarboxylic acid transporters), member 9 | solute carrier family 16, member 9 | solute carrier family 16 (monocarboxylic acid transporters)
Genes SLC16A9 (Hs), Slc16a9 (Mm)
Ensembl ID ENSG00000165449 (Hs), ENSMUSG00000037762 (Mm)
UniProtKB AC Q7RTY1 (Hs), Q7TM99 (Mm)
Bioparadigms SLC Tables SLC16A9 (Hs)
RESOLUTE SLC16A9 (Hs)
Stoichiometry Unknown

TAT1 (Monocarboxylate transporter 10 / SLC16A10) C Show summary »

MCT11 (Monocarboxylate transporter 11 / SLC16A11) Show summary »

MCT12 (Monocarboxylate transporter 12 / SLC16A12) Show summary »

MCT13 (Monocarboxylate transporter 13 / SLC16A13) Show summary »

MCT14 (Monocarboxylate transporter 14 / SLC16A14) Show summary »

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Further reading

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References

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How to cite this family page

Database page citation:

SLC16 family of monocarboxylate transporters. Accessed on 22/07/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=188.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.