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SLC29 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SLC29 family members are composed of 11 TM segments with cytoplasmic N-termini and extracellular C-termini. ENT1, ENT2 and ENT4 are primarily cell-surface transporters, while ENT3 is intracellular, possibly lysosomal [2]]. ENT2 isoforms may also play a role in the nucleolar transport of nucleosides [9]. ENT1-3 are described as broad-spectrum equilibrative nucleoside transporters. ENT4 is primarily a polyspecific organic cation transporter at neutral pH [12], but transports adenosine and analogues such as 2-chloroadenosine, with affinities similar to other members of the SLC29 family, at acidic pH [17].

Transporters

1118
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ENT1 (Equilibrative nucleoside transporter 1 / SLC29A1) C Show summary »

ENT2 (Equilibrative nucleoside transporter 2 / SLC29A2) C Show summary »


Target Id 1118
Nomenclature Equilibrative nucleoside transporter 2
Systematic nomenclature SLC29A2
Common abbreviation ENT2
Previous and unofficial names DER12 | HNP36 | equilibrative NBMPR-insensitive nucleoside transporter | equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter | nucleoside transporter, ei-type | solute carrier family 29 (nucleoside transporters) member 2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | solute carrier family 29 (nucleoside transporters)
Genes SLC29A2 (Hs), Slc29a2 (Mm), Slc29a2 (Rn)
Ensembl ID ENSG00000174669 (Hs), ENSMUSG00000024891 (Mm), ENSRNOG00000020025 (Rn)
UniProtKB AC Q14542 (Hs), Q61672 (Mm), O54699 (Rn)
Bioparadigms SLC Tables SLC29A2 (Hs)
Endogenous substrates
adenosine
inosine
hypoxanthine
guanine
uridine
guanosine
thymine
thymidine
cytosine
Substrates
2-chloroadenosine
formycin B
tubercidin
gemcitabine
cladribine
vidarabine
zidovudine
cytarabine
Stoichiometry Equilibrative

ENT3 (Equilibrative nucleoside transporter 3 / SLC29A3) C Show summary »

PMAT (Plasma membrane monoamine transporter / SLC29A4) C Show summary »

Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters. Br J Pharmacol. 178 Suppl 1:S412-S513.