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SLC29 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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SLC29 family members are composed of 11 TM segments with cytoplasmic N-termini and extracellular C-termini. ENT1, ENT2 and ENT4 are primarily cell-surface transporters, while ENT3 is intracellular, possibly lysosomal [2]]. ENT2 isoforms may also play a role in the nucleolar transport of nucleosides [9]. ENT1-3 are described as broad-spectrum equilibrative nucleoside transporters. ENT4 is primarily a polyspecific organic cation transporter at neutral pH [12], but transports adenosine and analogues such as 2-chloroadenosine, with affinities similar to other members of the SLC29 family, at acidic pH [17].


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ENT1 (Equilibrative nucleoside transporter 1 / SLC29A1) C Show summary »

ENT2 (Equilibrative nucleoside transporter 2 / SLC29A2) C Show summary »

ENT3 (Equilibrative nucleoside transporter 3 / SLC29A3) C Show summary »

Target Id 1119
Nomenclature Equilibrative nucleoside transporter 3
Systematic nomenclature SLC29A3
Common abbreviation ENT3
Previous and unofficial names solute carrier family 29 (nucleoside transporters), member 3 | solute carrier family 29 (equilibrative nucleoside transporter), member 3 | solute carrier family 29 (nucleoside transporters)
Genes SLC29A3 (Hs), Slc29a3 (Mm), Slc29a3 (Rn)
Ensembl ID ENSG00000198246 (Hs), ENSMUSG00000020100 (Mm), ENSRNOG00000000568 (Rn)
UniProtKB AC Q9BZD2 (Hs), Q99P65 (Mm), Q80WK7 (Rn)
Bioparadigms SLC Tables SLC29A3 (Hs)
Endogenous substrates
adenosine [2]
inosine [2]
uridine [2]
guanosine [2]
thymidine [2]
adenine [2]
cordycepin [2]
zebularine [2]
tubercidin [2]
cladribine [2]
floxuridine [2]
fludarabine [2]
zidovudine [2]
zalcitabine [2]
didanosine [2]
Stoichiometry Equilibrative
Comment Defects in SLC29A3 have been implicated in histiocytosis-lymphadenopathy plus syndrome (OMIM:602782) and lysosomal storage diseases [13-14].

PMAT (Plasma membrane monoamine transporter / SLC29A4) C Show summary »

Further reading

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.