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M12: Astacin/Adamalysin C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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ADAM (A Disintegrin And Metalloproteinase domain containing proteins) metalloproteinases cleave cell-surface or transmembrane proteins to generate soluble and membrane-limited products.

ADAMTS (with thrombospondin motifs) metalloproteinases cleave cell-surface or transmembrane proteins to generate soluble and membrane-limited products.

Enzymes

1663
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ADAM2 Show summary »

ADAM7 Show summary »

ADAM8 Show summary » More detailed page go icon to follow link

ADAM9 Show summary » More detailed page go icon to follow link

ADAM10 Show summary » More detailed page go icon to follow link

ADAM11 Show summary »

ADAM12 Show summary » More detailed page go icon to follow link

ADAM15 Show summary »

ADAM17 Show summary » More detailed page go icon to follow link

ADAM18 Show summary »


Target Id 1663
Nomenclature ADAM18
Previous and unofficial names ADAM27 | Dtgn3 | tMDCIII | Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III, tMDC III, ADAM27
Genes ADAM18 (Hs), Adam18 (Mm), Adam18 (Rn)
Ensembl ID ENSG00000168619 (Hs), ENSMUSG00000031552 (Mm), ENSRNOG00000017683 (Rn)
UniProtKB AC Q9Y3Q7 (Hs), Q9R157 (Mm), P97776 (Rn)

ADAM19 Show summary »

ADAM20 Show summary »

ADAM21 Show summary »

ADAM22 Show summary »

ADAM23 Show summary »

ADAM28 Show summary »

ADAM29 Show summary »

ADAM30 Show summary »

ADAM32 Show summary »

ADAM33 Show summary » More detailed page go icon to follow link

ADAMTS1 Show summary » More detailed page go icon to follow link

ADAMTS2 Show summary »

ADAMTS3 Show summary »

ADAMTS4 Show summary » More detailed page go icon to follow link

ADAMTS5 Show summary » More detailed page go icon to follow link

ADAMTS6 Show summary »

ADAMTS7 Show summary »

ADAMTS8 Show summary »

ADAMTS9 Show summary »

ADAMTS10 Show summary »

ADAMTS12 Show summary »

ADAMTS13 Show summary »

ADAMTS14 Show summary »

ADAMTS15 Show summary »

ADAMTS16 Show summary »

ADAMTS17 Show summary »

ADAMTS18 Show summary »

ADAMTS19 Show summary »

ADAMTS20 Show summary »

bone morphogenetic protein 1 Show summary » More detailed page go icon to follow link

Comments

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References

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How to cite this family page

Database page citation:

M12: Astacin/Adamalysin. Accessed on 25/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=739.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.