ADAM9 | M12: Astacin/Adamalysin | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 1657

Nomenclature: ADAM9

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 819 8p11.23 ADAM9 ADAM metallopeptidase domain 9
Mouse - 845 8 A2 Adam9 a disintegrin and metallopeptidase domain 9 (meltrin gamma)
Rat - 845 16q12.4 Adam9 ADAM metallopeptidase domain 9
Previous and Unofficial Names
cellular disintegrin-related protein | myeloma cell metalloproteinase | cone rod dystrophy 9 | disintegrin and metalloproteinase domain-containing protein 9 | MDC9 | Mltng | CORD9 | MCMP
Database Links
Specialist databases
MEROPS M12.209 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ilomastat Hs Inhibition 9.0 pIC50 1
pIC50 9.0 (IC50 1x10-9 M) [1]
Description: Measured in an in vitro assay.
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0042117 monocyte activation IMP
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0034612 response to tumor necrosis factor IDA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0042117 monocyte activation IMP
Clinically-Relevant Mutations and Pathophysiology
Disease:  Cone-rod dystrophy 9; CORD9
Synonyms: Cone rod dystrophy [Orphanet: ORPHA1872] [Disease Ontology: DOID:0050572]
Disease Ontology: DOID:0050572
OMIM: 612775
Orphanet: ORPHA1872


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1. Oh M, Im I, Lee YJ, Kim YH, Yoon JH, Park HG, Higashiyama S, Kim YC, Park WJ. (2004) Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors. Bioorg. Med. Chem. Lett., 14 (24): 6071-4. [PMID:15546732]

How to cite this page

M12: Astacin/Adamalysin: ADAM9. Last modified on 29/07/2015. Accessed on 27/05/2020. IUPHAR/BPS Guide to PHARMACOLOGY,