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R12 family C

Formerly known as: D family of RGS proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The R12 family consisting of RGS10, 12 and 14. RGS12 and 14 are large proteins with additional domains that can participate in protein-protein interactions and other functions. In contrast, RGS10 is a small protein consisting of the RGS domain and small N- and C-termini, similar to members of the R4 family. However, the sequence homology the RGS10 RGS domain clearly places it in the R12 family [2]. The Gαi/o-Loco (GoLoco) motif in RGS12 and 14 has GDI activity (for Guanine nucleotide Dissociation Inhibitor) towards Gαi1, Gαi2 and Gαi3 [1,4]. Through this activity RGS12 and RGS14 can inhibit G protein signaling both by accelerating GTP hydrolysis and by preventing G protein activation. Splice variants of RGS12 and RGS14 also contain membrane targeting and protein-protein interaction domains [3,5-6].


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RGS10 (regulator of G-protein signaling 10) C Show summary » More detailed page go icon to follow link

RGS12 (regulator of G-protein signaling 12) C Show summary » More detailed page go icon to follow link

RGS14 (regulator of G-protein signaling 14) C Show summary » More detailed page go icon to follow link


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.