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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase (GTP diphosphate-lyase (cyclising)), E.C., is a heterodimer comprising a β1 subunit and one of two alpha subunits (α1, α2) giving rise to two functionally indistinguishable isoforms, GC-1 (α1β1) and GC-2 (α2β1) [13,19]. A haem group is associated with the β subunit and is the target for the endogenous ligand NO, and, potentially, carbon monoxide [5].


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GC-1 (Guanylyl cyclase, α1β1) C Show summary » More detailed page go icon to follow link

GC-2 (Guanylyl cyclase, α2β1) C Show summary » More detailed page go icon to follow link

Receptors and Subunits

Guanylyl cyclase α1 subunit C Show summary »

Target Id 1288
Nomenclature Guanylyl cyclase α1 subunit
Previous and unofficial names GCS-alpha-1 | GCS-alpha-3 | guanylate cyclase 1, soluble, alpha 3 | SGC | soluble guanylate cyclase | soluble guanylate cyclase large subunit | alpha 1 sGC | GC-SA3 | guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase) | guanylate cyclase 1 | GUCY1A3 | guanylate cyclase 1 soluble subunit alpha | Gucy1a3 | guanylate cyclase 1 soluble subunit alpha 3 | guanylate cyclase 1, soluble, alpha 1
Complexes GC-1 (Guanylyl cyclase, α1β1)
Genes GUCY1A1 (Hs), Gucy1a1 (Mm), Gucy1a1 (Rn)
Ensembl ID ENSG00000164116 (Hs), ENSMUSG00000033910 (Mm), ENSRNOG00000012302 (Rn)
UniProtKB AC Q02108 (Hs), Q9ERL9 (Mm), P19686 (Rn)

Guanylyl cyclase α2 subunit C Show summary »

Guanylyl cyclase β1 subunit C Show summary »

Guanylyl cyclase β2 subunit C Show summary »


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.