mAbs | Trade name | Target | Indication |
---|---|---|---|
Ramucirumab (Cyramza) | Cyramza | VEGFR-2 | Advanced/metastatic gastric or gastroesophageal junction adenocarcinoma; metastatic non-small cell lung cancer; metastatic colorectal cancer |
Panitumumab (Vectibix) | Vectibix | EGFR | EGFR-expressing colorectal cancer |
Pertuzumab (Perjeta) | Perjeta | HER2 | Metastatic HER2-overexpressing breast cancer |
Cetuximab (Erbitux) | Erbitux | EGFR | Metastatic KRAS negative colorectal cancer; squamous cell carcinoma of the head and neck |
Trastuzumab | Herceptin, Herclon | HER2 | HER2/neu overexpressing breast cancer, some gastric adenocarcinomas |
ADC | |||
Ado-trastuzumab emtansine | Kadcyla | HER2 | Metastatic HER2 over-expressing breast cancer |
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To cite this family introduction, please use the following:
Kinases (EC 2.7.x.x), introduction. Last modified on 30/06/2020. Accessed on 22/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyIntroductionForward?familyId=698.