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ChEMBL ligand: CHEMBL33 (Cravit, DR-3355, Evoxil, Floxacin, Iquix, Levaquin, Levofloxacin, Levofloxacin anhydrous, Levofloxacin (as hemihydrate), Levofloxacin hemihydrate, Levofloxacin hydrate, L-ofloxacin, Nofaxin, NSC-758709, Ofloxacin, (s)-, Ofloxacin s-(-)-form, Ofloxacin s-(-)-form hemihydrate, Oftaquix, Quinsair, Quixin, RWJ-25213, Tavanic, Volequin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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DNA gyrase subunit A in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4165] [UniProtKB: P9WG47] | ||||||||
ChEMBL | Inhibition of DNA supercoiling activity of wild type Mycobacterium tuberculosis DNA gyrase A | B | 4.28 | pIC50 | 52000 | nM | IC50 | Antimicrob Agents Chemother (2010) 54: 3478-3480 [PMID:20516287] |
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8] | ||||||||
ChEMBL | Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay | B | 4.75 | pIC50 | 17900 | nM | IC50 | J Med Chem (2013) 56: 781-795 [PMID:23241029] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR Green-1 staining based fluorescence assay | F | 4.7 | pIC50 | >20000 | nM | IC50 | Eur J Med Chem (2017) 139: 22-47 [PMID:28800458] |
Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] | ||||||||
ChEMBL | MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate | F | 5.12 | pIC50 | 7600 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]