domatinostat [Ligand Id: 14330] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4283683 (4sc-202, Domatinostat, Hdac inhibitor 4sc-202) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 5.92 | pIC50 | 1200 | nM | IC50 | ACS Med Chem Lett (2020) 11: 713-719 [PMID:32435375] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent method | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2021) 216: 113332-113332 [PMID:33714914] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2024) 264: 115999-115999 [PMID:38043489] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) by fluorescence based analysis | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2024) 67: 922-951 [PMID:38214982] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2021) 222: 113588-113588 [PMID:34107385] |
| ChEMBL | Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate incubated for 30 mins by fluorescence assay | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem (2024) 101: 117651-117651 [PMID:38401457] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 6.8 | pIC50 | 160 | nM | IC50 | Eur J Med Chem (2023) 259: 115673-115673 [PMID:37487305] |
| GtoPdb | - | - | 6.8 | pIC50 | 160 | nM | IC50 | Eur J Med Chem (2020) 192: 112171 [PMID:32163814] |
| ChEMBL | Inhibition of HDAC1 (unknown origin) | B | 9.8 | pIC50 | 0.16 | nM | IC50 | Eur J Med Chem (2020) 192: 112171-112171 [PMID:32163814] |
| histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] | ||||||||
| ChEMBL | Inhibition of HDAC11 (unknown origin) using p53 (379 to 382 residues)(RHKK(Ac)-AMC) as substrate by fluorescent method | B | 5.01 | pIC50 | 9700 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of HDAC11 (unknown origin) | B | 5.01 | pIC50 | 9700 | nM | IC50 | Eur J Med Chem (2021) 216: 113332-113332 [PMID:33714914] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC2 incubated for 60 mins by fluorescence based assay | B | 5.95 | pIC50 | 1120 | nM | IC50 | Bioorg Med Chem (2024) 101: 117651-117651 [PMID:38401457] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) | B | 5.95 | pIC50 | 1120 | nM | IC50 | Eur J Med Chem (2021) 216: 113332-113332 [PMID:33714914] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) | B | 5.95 | pIC50 | 1120 | nM | IC50 | Eur J Med Chem (2024) 264: 115999-115999 [PMID:38043489] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) | B | 5.95 | pIC50 | 1120 | nM | IC50 | Eur J Med Chem (2021) 222: 113588-113588 [PMID:34107385] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent method | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of human recombinant HDAC2 using ArgHisLysLys(Ac) as substrate by fluorescence based analysis | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2024) 67: 922-951 [PMID:38214982] |
| GtoPdb | - | - | 6.43 | pIC50 | 370 | nM | IC50 | Eur J Med Chem (2020) 192: 112171 [PMID:32163814] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) | B | 6.43 | pIC50 | 370 | nM | IC50 | Eur J Med Chem (2023) 259: 115673-115673 [PMID:37487305] |
| ChEMBL | Inhibition of HDAC2 (unknown origin) | B | 6.43 | pIC50 | 370 | nM | IC50 | Eur J Med Chem (2020) 192: 112171-112171 [PMID:32163814] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC3 expressed in baculovirus infected insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr by fluorescence based analysis | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2024) 67: 922-951 [PMID:38214982] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent method | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 6.24 | pIC50 | 570 | nM | IC50 | Eur J Med Chem (2024) 264: 115999-115999 [PMID:38043489] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 6.24 | pIC50 | 570 | nM | IC50 | Eur J Med Chem (2021) 216: 113332-113332 [PMID:33714914] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 6.24 | pIC50 | 570 | nM | IC50 | Eur J Med Chem (2021) 222: 113588-113588 [PMID:34107385] |
| ChEMBL | Inhibition of human recombinant HDAC3 incubated for 60 mins by fluorescence based assay | B | 6.24 | pIC50 | 570 | nM | IC50 | Bioorg Med Chem (2024) 101: 117651-117651 [PMID:38401457] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2023) 259: 115673-115673 [PMID:37487305] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2020) 192: 112171-112171 [PMID:32163814] |
| ChEMBL | Inhibition of HDAC3 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2018) 157: 1127-1142 [PMID:30179749] |
| GtoPdb | - | - | 6.89 | pIC50 | 130 | nM | IC50 | Eur J Med Chem (2020) 192: 112171 [PMID:32163814] |
| histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
| ChEMBL | Inhibition of HDAC4 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] | ||||||||
| ChEMBL | Inhibition of HDAC5 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of HDAC6 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] | ||||||||
| ChEMBL | Inhibition of HDAC7 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| ChEMBL | Inhibition of HDAC8 (unknown origin) using p53 (379 to 382 residues)(RHK(Ac)K(ac)AMC) as substrate by fluorescent method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] | ||||||||
| ChEMBL | Inhibition of HDAC9 (unknown origin) | B | 4.3 | pIC50 | 50000 | nM | IC50 | Eur J Med Chem (2021) 216: 113332-113332 [PMID:33714914] |
| ChEMBL | Inhibition of HDAC9 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
| lysine demethylase 1A/Lysine-specific histone demethylase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341] | ||||||||
| ChEMBL | Inhibition of LSD-1 (unknown origin) | B | 5.92 | pIC50 | 1200 | nM | IC50 | Eur J Med Chem (2023) 259: 115673-115673 [PMID:37487305] |
| ChEMBL | Inhibition of human LSD1 (unknown orgin) | B | 6.22 | pIC50 | 600 | nM | IC50 | Eur J Med Chem (2021) 222: 113588-113588 [PMID:34107385] |
| ChEMBL | Inhibition of human N-terminal His-tagged LSD1 using histone H3 peptide (1 to 21 residues) K4me2 as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hrs by fluorescence analysis | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem (2024) 101: 117651-117651 [PMID:38401457] |
| ChEMBL | Inhibition of KDM1A/LSD1 (unknown origin) | B | 6.22 | pIC50 | 600 | nM | IC50 | ACS Med Chem Lett (2020) 11: 713-719 [PMID:32435375] |
| ChEMBL | Inhibition of LSD1 (unknown origin) | B | 6.22 | pIC50 | 600 | nM | IC50 | Eur J Med Chem (2024) 264: 115999-115999 [PMID:38043489] |
| ChEMBL | Inhibition of human LSD1 by luminescence assay | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2024) 67: 922-951 [PMID:38214982] |
| ChEMBL | Inhibition of LSD1 (unknown origin) | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2023) 66: 4275-4293 [PMID:37014989] |
| histone deacetylase 10/Polyamine deacetylase HDAC10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] | ||||||||
| ChEMBL | Inhibition of HDAC10 (unknown origin) | B | 4.68 | pIC50 | 21000 | nM | IC50 | Eur J Med Chem (2021) 216: 113332-113332 [PMID:33714914] |
| ChEMBL | Inhibition of HDAC10 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2020) 63: 12460-12484 [PMID:32608981] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
